Faculty Articles
Genetic Instability and Hematologic Disease Risk in Werner Syndrome Patients and Heterozygotes
Publication Title
Cancer Research
ISSN
0008-5472
Publication Date
5-1-2000
Abstract
Werner syndrome (WRN) is an uncommon autosomal recessive disease in which progeroid features are associated with genetic instability and an elevated risk of neoplasia. We have used the glycophorin A (GPA) somatic cell mutation assay to analyze genetic instability in vivo in WRN patients and heterozygotes. GPA variant frequencies were determined for 11 WRN patients and for 10 heterozygous family members who collectively carry 10 different WRN mutations. Genetic instability as measured by GPA Ø/N allele loss variant frequency was significantly increased, and this increase was strongly age-dependent in WRN patients. GPA Ø/N allele loss variants were also significantly elevated in heterozygous family members, thus providing the first evidence for in vivo genetic instability in heterozygous carriers in an autosomal recessive genetic instability syndrome. Our results and comparable data on other human genetic instability syndromes allow an estimate of the level of genetic instability that increases the risk of human bone marrow dysfunction or neoplasia.
Volume
60
Issue
9
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
NSUWorks Citation
Moser, Michael J.; Bigbee, William L.; Grant, Stephen G.; Emond, Mary J.; Langlois, Richard G.; Jensen, Ronald H.; Oshima, Junko; and Monnat, Jr, Raymond J., "Genetic Instability and Hematologic Disease Risk in Werner Syndrome Patients and Heterozygotes" (2000). Faculty Articles. 896.
https://nsuworks.nova.edu/hpd_com_faculty_articles/896
