Accumulation of D-Aspartic Acid with Age in the Human Brain

Authors

Eugene H. Man
Mark Sandhouse, Nova Southeastern UniversityFollow
Jonathan Burg
George H. Fisher

Publication Title

Science

Publication Date

6-1-1983

Abstract

An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.

Volume

220

Issue

4604

First Page

1407

Last Page

1408

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

NSUWorks Citation

Man, Eugene H.; Sandhouse, Mark; Burg, Jonathan; and Fisher, George H., "Accumulation of D-Aspartic Acid with Age in the Human Brain" (1983). Faculty Articles. 560.
https://nsuworks.nova.edu/hpd_com_faculty_articles/560