Faculty Articles

Title

Reduction of immune activation with chloroquine therapy during chronic HIV infection.

ISBN or ISSN

0022-538X

Publication Title

Journal of virology

Volume

84

Issue

22

Publication Date / Copyright Date

11-1-2010

First Page

12082

Last Page

12086

Publisher

American Society For Microbiology

DOI Number

10.1128/JVI.01466-10

Abstract

Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR(+) CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.

Disciplines

Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy

Keywords

CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cells, Cultured, Chloroquine, Chronic Disease, Down-Regulation, HIV Infections, Humans, Ki-67 Antigen, Leukocytes, Mononuclear, Lymphocyte Activation

Peer Reviewed

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