Faculty Articles
Reduction of immune activation with chloroquine therapy during chronic HIV infection.
Publication Title
Journal of virology
Publisher
American Society For Microbiology
ISSN
0022-538X
Publication Date
11-1-2010
Keywords
CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cells, Cultured, Chloroquine, Chronic Disease, Down-Regulation, HIV Infections, Humans, Ki-67 Antigen, Leukocytes, Mononuclear, Lymphocyte Activation
Abstract
Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR(+) CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.
DOI
10.1128/JVI.01466-10
Volume
84
Issue
22
First Page
12082
Last Page
12086
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
NSUWorks Citation
Murray, Shannon Marie; Down, Carrie M; Boulware, David R; Stauffer, William M; Cavert, Winston P; Schacker, Timothy W; Brenchley, Jason M; and Douek, Daniel C, "Reduction of immune activation with chloroquine therapy during chronic HIV infection." (2010). Faculty Articles. 1552.
https://nsuworks.nova.edu/hpd_com_faculty_articles/1552
