Student Theses, Dissertations and Capstones

Document Type

Thesis - NSU Access Only

Degree Name

Master of Science (M.S.) in Dentistry

Copyright Statement

All rights reserved. This publication is intended for use solely by faculty, students, and staff of Nova Southeastern University. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.

Department

College of Dental Medicine

First Advisor

Theofilos Koutouzis

Date of original Performance / Presentation

January 2025

Publication Date / Copyright Date

1-1-2025

Abstract

Objective. The present study compared two biologic agents that are widely used in periodontal regeneration procedures. Emdogain (EMD) functions to differentiate cells of the dental follicle into cementoblasts. Plasma-derived growth factor (rh-PDGF) helps in recruiting undifferentiated mesenchymal cells, consequently boosting the healing process of the wounds. The aim of this study was to compare the effect of rh-PDGF to EMD on clinical measures such as probing depth, gingival recession, vertical clinical attachment loss, and radiographic measures following 6 months of healing. Methods. This RCT included twelve patients with twenty intrabony defects. Participants were adults in good general health, presenting with probing depth of ≥ 6 mm and radiographic evidence of intrabony defects. Patients were randomly assigned to receive either rh-PDGF (test group) or EMD (control group) with allogenic bone graft. All surgical procedures were performed in the Periodontics Department at Nova Southeastern University. Baseline, intrasurgical measurements and radiographic were collected. Clinical parameters, including probing depth (PD), clinical attachment level (CAL), and recession (REC) were recorded at baseline and at six-month re-evaluation. Radiographic bone fill and defect angle were assessed using digital imaging software. Data analysis was conducted with primary outcome being CAL change. Results. At baseline, there were no significant differences for clinical (PD, CAL, REC), intrasurgical (intrabony depth and width), and radiographs (bone level and angle) variables. Both groups displayed significant improvements in PD (rh-PDGF 3.6 ± 1.71mm, p < 0.001, EMD 3.5 ± 1.43mm, p < 0.001) and CAL (rh-PDGF 3.3 ± 1.88mm, p < 0.001, EMD 3.0 ± 1.88mm, p < 0.002), and BOP (p < 0.001) at six months. No significant differences observed for recession at Baseline and six months. There was no statistically significant difference between both groups for PD (p = 0.762), REC (p = 0.841), CAL (p = 0.912), and PD reduction (p = 0.889). Additionally, there were no statistically significant differences between radiographic bone fill and angle between the groups. Conclusions. The study failed to identify differences between groups in improving clinical parameters. Both treatment modalities appeared equally effective in decreasing probing depth, increasing clinical attachment levels, reducing BOP and achieving successful radiographic outcomes.

Disciplines

Dentistry

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