Faculty Articles

A mucoadhesive mouth wash, reduces the signs and symptoms of oral mucositis in patients with lichen planus: a double-blind randomized-control pilot study

Publication Title

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

Publisher

Elsevier

ISSN

2212-4403

Publication Date

12-1-2014

Abstract

Objective
To determine if MuGard, a mouthwash shown to reduce the severity of oral mucositis when started before initiating antineoplastic therapy for head and neck cancers, is effective when painful, oral lesions are present in patients with biopsy-proven erosive oral lichen planus.

Study Design
This was a double-blind, randomized, placebo-controlled pilot study at a college of dental medicine. Twenty patients with oral lichen planus were randomly assigned to receive either MuGard (n = 10) or saline-bicarbonate control (n = 10). One teaspoonful of the assigned mouthwash was swished for 1 minute, 5 times a day, for 14 days. Outcome measures (Oral Mucositis Assessment Scale scores and visual analog scale pain scores) were obtained before the start of treatment and repeated on days 2, 7, and 14.

Results
Significant reductions in all outcome measures occurred in the MuGard-treated group. Number-needed-to-treat (NNT) to achieve a >50% reduction in averaged pain from baseline was 1.25, and to obtain complete relief, the NNT was 2.5.

Conclusions
MuGard significantly reduces pain and ulceration associated with oral mucositis in patients with lichen planus.

DOI

10.1016/j.oooo.2014.07.007

Issue

6

First Page

657

Last Page

664

Disciplines

Dentistry

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Peer Reviewed

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