Speaker Credentials
MS-III
Speaker Credentials
MD
College
College of Allopathic Medicine
Medical Specialty
Internal Medicine
Format
Poster
Start Date
November 2024
End Date
November 2024
Track
2
Abstract
Exploring the COVID-19 Vaccine: New Onset and Exacerbations in Rheumatic Diseases Sania Siddiqui, Anita Laloo MD, MPH Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine (NSU MD) Objective: This study aims to explore the rheumatological manifestations associated with the COVID-19 vaccine. Background: The Coronavirus disease (COVID-19) vaccine has proven effective in mitigating the transmission of SARS-CoV-2 and reducing global disease burden. There is limited understanding regarding the exacerbations of pre-existing rheumatological disorders and new-onset joint disease following vaccination. Methods: A narrative literature search was conducted on PubMed, Google Scholar, and SCOPUS. No restrictions regarding the publication date, language, or country of origin were applied. Twenty relevant studies were identified focused on rheumatological outcomes post COVID-19 vaccination. Results: Joint-related symptoms commonly reported following COVID-19 vaccination include joint pain, swelling, and limited range of motion, typically emerging within 1 to 3 weeks post-vaccination. Current literature supports a polyarticular distribution, affecting both large and small joints. The three most common new-onset rheumatic conditions were vasculitis, inflammatory arthritis, and connective tissue disease. Risk factors associated with flare ups include female sex, history of previous vaccine reactions, and higher disease activity prior to vaccination. For both groups, symptomatic improvement and remission with steroids and other immunosuppressive agents was noted. Conclusion: The relationship between the COVID-19 vaccine and rheumatological disease is complex, likely mediated by molecular mimicry and autoreactive immune responses. Understanding these pathways is crucial as clinicians navigate the diagnosis and management of vaccine-associated rheumatological manifestations.
Included in
Exploring the COVID-19 Vaccine: New Onset and Exacerbations in Rheumatic Diseases
Exploring the COVID-19 Vaccine: New Onset and Exacerbations in Rheumatic Diseases Sania Siddiqui, Anita Laloo MD, MPH Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine (NSU MD) Objective: This study aims to explore the rheumatological manifestations associated with the COVID-19 vaccine. Background: The Coronavirus disease (COVID-19) vaccine has proven effective in mitigating the transmission of SARS-CoV-2 and reducing global disease burden. There is limited understanding regarding the exacerbations of pre-existing rheumatological disorders and new-onset joint disease following vaccination. Methods: A narrative literature search was conducted on PubMed, Google Scholar, and SCOPUS. No restrictions regarding the publication date, language, or country of origin were applied. Twenty relevant studies were identified focused on rheumatological outcomes post COVID-19 vaccination. Results: Joint-related symptoms commonly reported following COVID-19 vaccination include joint pain, swelling, and limited range of motion, typically emerging within 1 to 3 weeks post-vaccination. Current literature supports a polyarticular distribution, affecting both large and small joints. The three most common new-onset rheumatic conditions were vasculitis, inflammatory arthritis, and connective tissue disease. Risk factors associated with flare ups include female sex, history of previous vaccine reactions, and higher disease activity prior to vaccination. For both groups, symptomatic improvement and remission with steroids and other immunosuppressive agents was noted. Conclusion: The relationship between the COVID-19 vaccine and rheumatological disease is complex, likely mediated by molecular mimicry and autoreactive immune responses. Understanding these pathways is crucial as clinicians navigate the diagnosis and management of vaccine-associated rheumatological manifestations.