Faculty Books and Book Chapters
Increasing Resilience to Traumatic Stress: Understanding the Protective Role of Well-Being
Book Title
Psychoneuroimmunology: Methods and Protocols
Document Type
Book Chapter
ISBN
978-1493978274
Publication Date
2018
Description
The brain maintains homeostasis in part through a network of feedback and feed-forward mechanisms, where neurochemicals and immune markers act as mediators. Using a previously constructed model of biobehavioral feedback, we found that in addition to healthy equilibrium another stable regulatory program supported chronic depression and anxiety. Exploring mechanisms that might underlie the contributions of subjective well-being to improved therapeutic outcomes in depression, we iteratively screened 288 candidate feedback patterns linking well-being to molecular signaling networks for those that maintained the original homeostatic regimes. Simulating stressful trigger events on each candidate network while maintaining high levels of subjective well-being isolated a specific feedback network where well-being was promoted by dopamine and acetylcholine, and itself promoted norepinephrine while inhibiting cortisol expression. This biobehavioral feedback mechanism was especially effective in reproducing well-being’s clinically documented ability to promote resilience and protect against onset of depression and anxiety.
Publisher
Humana Press
City
New York, NY
First Page
87
Last Page
100
NSUWorks Citation
Toole, J. T.,
Rice Jr., M. A.,
Cargill, J.,
Craddock, T. J.,
Nierenberg, B. P.,
Klimas, N. G.,
Fletcher, M. A.,
Morris, M.,
Zysman, J. P.,
Broderick, G.
(2018). Increasing Resilience to Traumatic Stress: Understanding the Protective Role of Well-Being. Psychoneuroimmunology: Methods and Protocols, 87-100.
Available at: https://nsuworks.nova.edu/cps_facbooks/567
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Additional Information
Qing Yan, Editor.