Faculty Books and Book Chapters
Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression
Book Title
Psychoneuroimmunology: Methods and Protocols
Document Type
Book Chapter
ISBN
978-1493978274
Publication Date
2018
Description
We propose that the complexity of regulatory interactions modulating brain neurochemistry and behavior is such that multiple stable responses may be supported, and that some of these alternate regulatory programs may play a role in perpetuating persistent psychological dysfunction. To explore this, we constructed a model network representing major neurotransmission and behavioral mechanisms reported in literature as discrete logic circuits. Connectivity and information flow through this biobehavioral circuitry supported two distinct and stable regulatory programs. One such program perpetuated a depressive state with a characteristic neurochemical signature including low serotonin. Further analysis suggested that small irregularities in glutamate levels may render this pathology more directly accessible. Computer simulations mimicking selective serotonin reuptake inhibitor (SSRI) therapy in the presence of everyday stressors predicted recidivism rates similar to those reported clinically and highlighted the potentially significant benefit of concurrent behavioral stress management therapy.
Publisher
Humana Press
City
New York, NY
First Page
121
Last Page
124
NSUWorks Citation
Toole, J. T.,
Rice, M. A.,
Craddock, T. J.,
Nierenberg, B. P.,
Klimas, N. G.,
Fletcher, M. A.,
Zysman, J. P.,
Morris, M.,
Broderick, G.
(2018). Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression. Psychoneuroimmunology: Methods and Protocols, 121-124.
Available at: https://nsuworks.nova.edu/cps_facbooks/566
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Additional Information
Qing Yan, Editor.