College of Psychology: Faculty Articles

Title

Effects of Long-Term Neuroleptic Use on Brain Density

Document Type

Article

Publication Date

8-1981

Keywords

Schizophrenia, Brain Density, CT Scan, Neuroleptics, Brain Damage.

Publication Title

Psychiatry Research

ISSN

0165-1781

Volume

5

Issue/No.

1

Abstract

Mean density values of the brain in four quadrants were determined for a sample of 16 chronic schizophrenic patients who had received between 0 and 3,000 grams of lifetime neuroleptics. Significant correlations were found between the measures of density in the posterior quadrants of both hemispheres and total lifetime medication usage. Correlations with anterior density were insignificant. Corrections for age and current severity of the disorder (as measured by the Brief Psychiatric Rating Scale) did not alter the significant finding. Possible explanations for the results are discussed as well as their possible implications.

DOI

10.1016/0165-1781(81)90058-5

Peer Reviewed

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