Faculty Articles

Title

Feedback Regulation of Immune Response to Maximum Exercise in Gulf War Illness

Document Type

Article

Publication Date

9-2019

Publication Title

BCB '19: Proceedings of the 10th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics

First Page

124

Last Page

129

Abstract/Excerpt

Gulf War Illness is a disease that affects about a third of the veterans that served in the 1990-91 Persian Gulf War. The symptoms are varied, the cause is unknown, and there is no known treatment. In this paper we compare the dynamic characteristics of cytokines feedback response to exercise in n=12 veterans diagnosed with Gulf War Illness (GWI) and n=12 healthy veterans deployed to the same theatre of operations. A third-order transfer function is used to model the process dynamics of 18 cytokines projected onto principal components with a Proportional Integral Derivative (PID) controller enforcing the homeostatic regulation of these co-expression patterns. Transfer functions were fit to each subject for each principal component and the dynamic response parameters compared between the veteran control and GWI subject groups. Results of this analysis indicate that while much of the regulatory response dynamics are shared by both groups, there is a significant difference in the damping of the Th1:Th2 cytokine response to exercise in Gulf War Illness.

DOI

https://doi.org/10.1145/3307339.3342188

Peer Reviewed

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