Faculty Articles

Title

Water-Mediated Correlations in DNA-Enzyme Interactions

Document Type

Article

Publication Date

1-2018

Keywords

aromatic networks, dipole oscillations, EcoRI restriction endonuclease, quantum biologyTaq DNA polymerase, water dipole field

Publication Title

Physics Letters A

ISSN

0375-9601

Volume

382

Issue/No.

1

Abstract

In this letter we consider dipole-mediated correlations between DNA and enzymes in the context of their water environment. Such correlations emerge from electric dipole-dipole interactions between aromatic ring structures in DNA and in enzymes. We show that there are matching collective modes between DNA and enzyme dipole fields, and that a dynamic time-averaged polarization vanishes in the water dipole field only if either DNA, enzyme, or both are absent from the sample. This persistent field may serve as the electromagnetic image that, in popular colloquialisms about DNA biochemistry, allows enzymes to “scan” or “read” the double helix. Topologically nontrivial configurations in the coherent ground state requiring clamplike enzyme behavior on the DNA may stem, ultimately, from spontaneously broken gauge symmetries.

DOI

https://doi.org/10.1016/j.physleta.2017.10.038

Peer Reviewed

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