Chemistry and Physics Faculty Proceedings, Presentations, Speeches, Lectures
Amino-bis-phosphonate-containing polymers via RAFT polymerization
Event Name/Location
Patent: PCT/US2015/019892 Application: WO2015138566A1
Presentation Date
2014
Document Type
Patent
ORCID ID
0000-0002-7836-7262
Description
Subject polymers have a plurality of repeating units having amino-bis-phosphonate functionality pendent groups of a polyacrylate, polymethacrylate, polyacrylamide, polymethacrylamide, or linear polyethyleneimine. The polymers are prepared from a plurality of monomers comprising amino-te-phosphonate functionality or from a polymer having NHBoc or active ester pendent groups that are subsequently transformed into the amino-bis-phosphonate comprising polymer. The amino-bis-phosphonate comprising polymers or their precursor polymers can be prepared by RAFT polymerization or by transformation of a preformed polymer. The amino-bis-phosphonate comprising polymers can be linear or branched polymers. The amino-bis-phosphonate comprising polymers can be complexed with metal ions. The metal ions can be a radionuclide and the amino-bis-hosphonate comprising polymer complexes can be used as radiotherapeutic agents.
NSUWorks Citation
Schulz, Michael D.; Sumerlin, Brent S.; Wagener, Kenneth B.; Sparks, Chelsea A.; Batich, Christopher D.; Bolch, Wesley E.; Smith, Shanna M.; Bachler, Patricia R.; Milner, Rowan J.; Kwan, Michael; and Popwell, Sammy J., "Amino-bis-phosphonate-containing polymers via RAFT polymerization" (2014). Chemistry and Physics Faculty Proceedings, Presentations, Speeches, Lectures. 243.
https://nsuworks.nova.edu/cnso_chemphys_facpres/243
COinS
Comments
Classifications:
C08F220/34 Esters containing nitrogen C08F228/02 Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a bond to sulfur or by a heterocyclic ring containing sulfur by a bond to sulfur C08F230/02 Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus C08F8/40 Introducing phosphorus atoms or phosphorus-containing groups C08G73/00 Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00 C08G73/0206 Polyalkylene(poly)amines C08G73/0233 Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups C08F2438/03 Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]