Chemistry and Physics Faculty Proceedings, Presentations, Speeches, Lectures

Oxidative Deamination of Amino Acids by Molecular Oxygen with Pyridoxal Phosphate and Cu(II) Ion as Catalysts

Event Name/Location

8th International Symposium on Vitamin B6 and Carbonyl Catalysis, Osaka, Japan, October 15-19, 1990

Presentation Date

11-1-1991

Document Type

Conference Proceeding

Proceeding Title

Enzymes Dependent on Pyridoxal Phosphate and Other Carbonyl Compounds As Cofactors

ISBN

978-0-08-040820-0

Keywords

Oxidative deamination, Pyridoxal phosphate, p-suifophenylglycine, Oxygen insertion, Oxime formation, Monooxygenase model

Description

This paper reports the quantitative oxidation by molecular oxygen of the Cu(II) chelate of the Schiff base formed from vitamin B6 (pyridoxal phosphate, PLP) and p-sulfophenylglycine to the keto acid, p-sulfophenyl-glyoxylic acid, and the Cu(II) chelate of PLP oxime. In the presence of excess amino acid the Cu(II) chelate of the oxime becomes an intermediate in the oxidative deamination of the amino acid to the corresponding keto acid and ammonia, with Cu(II) and PLP as catalysts.

DOI

10.1016/B978-0-08-040820-0.50078-9

Publisher

Pergamon Press

Publisher Location

Oxford, United Kingdom

First Page

365

Last Page

369

Comments

©1991 Pergamon Press plc. Published by Elsevier Ltd. All rights reserved.

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