Fabrication of Core–Shell Nanoparticles via Controlled Aggregation of Semiflexible Conjugated Polymer and Hyaluronic Acid
Cells, Complexation, Fluorescence, Labeling, Nanoparticles
Core-shell conjugated polymer nanoparticles (CPNs) were fabricated by complexing a semi-flexible, primary amine-containing conjugated polymer (CP) with hyaluronic acid (HA). Flexibility introduced in the rigid rod conjugated backbone allows backbone reorganization to increase π-π interaction under ionic complexation, resulting in core-shell nanoparticles with a hydrophobic CP core wrapped with a HA shell. The core-shell nanoparticles exhibited no cellular toxicity and high cancer cell specificity with minimal binding to normal cells.
Twomey, M., Na, Y., Hakim, Z., Mendez, E., Panday, N., He, J., & Moon, J. H. (2013). Fabrication of Core–Shell Nanoparticles via Controlled Aggregation of Semiflexible Conjugated Polymer and Hyaluronic Acid. Macromolecules, 45, (15), 6374 - 6378. https://doi.org/10.1021/ma400996y. Retrieved from https://nsuworks.nova.edu/cnso_chemphys_facarticles/315