Chemistry and Physics Faculty Articles
Title
Fabrication of Core–Shell Nanoparticles via Controlled Aggregation of Semiflexible Conjugated Polymer and Hyaluronic Acid
Document Type
Article
Publication Date
8-2-2013
Publication Title
Macromolecules
Keywords
Cells, Complexation, Fluorescence, Labeling, Nanoparticles
ISSN
0024-9297
Volume
45
Issue/No.
15
First Page
6374
Last Page
6378
Abstract
Core-shell conjugated polymer nanoparticles (CPNs) were fabricated by complexing a semi-flexible, primary amine-containing conjugated polymer (CP) with hyaluronic acid (HA). Flexibility introduced in the rigid rod conjugated backbone allows backbone reorganization to increase π-π interaction under ionic complexation, resulting in core-shell nanoparticles with a hydrophobic CP core wrapped with a HA shell. The core-shell nanoparticles exhibited no cellular toxicity and high cancer cell specificity with minimal binding to normal cells.
NSUWorks Citation
Twomey, M., Na, Y., Hakim, Z., Mendez, E., Panday, N., He, J., & Moon, J. H. (2013). Fabrication of Core–Shell Nanoparticles via Controlled Aggregation of Semiflexible Conjugated Polymer and Hyaluronic Acid. Macromolecules, 45, (15), 6374 - 6378. https://doi.org/10.1021/ma400996y. Retrieved from https://nsuworks.nova.edu/cnso_chemphys_facarticles/315
DOI
10.1021/ma400996y
Comments
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