Fabrication of Core–Shell Nanoparticles via Controlled Aggregation of Semiflexible Conjugated Polymer and Hyaluronic Acid

Authors

Megan Twomey, Florida International University
Yoonmi Na, Florida International University
Zadok Hakim, Nova Southeastern UniversityFollow
Eladio Mendez, Florida International University
Namuna Panday, Florida International University
Jin He, Florida International University
Joong Ho Moon, Florida International University

Document Type

Article

Publication Title

Macromolecules

ISSN

0024-9297

Publication Date

8-2-2013

Keywords

Cells, Complexation, Fluorescence, Labeling, Nanoparticles

Abstract

Core-shell conjugated polymer nanoparticles (CPNs) were fabricated by complexing a semi-flexible, primary amine-containing conjugated polymer (CP) with hyaluronic acid (HA). Flexibility introduced in the rigid rod conjugated backbone allows backbone reorganization to increase π-π interaction under ionic complexation, resulting in core-shell nanoparticles with a hydrophobic CP core wrapped with a HA shell. The core-shell nanoparticles exhibited no cellular toxicity and high cancer cell specificity with minimal binding to normal cells.

DOI

10.1021/ma400996y

Volume

45

Issue

15

First Page

6374

Last Page

6378

Comments

Copyright © 2013 American Chemical Society

NSUWorks Citation

Twomey, M., Na, Y., Hakim, Z., Mendez, E., Panday, N., He, J., & Moon, J. H. (2013). Fabrication of Core–Shell Nanoparticles via Controlled Aggregation of Semiflexible Conjugated Polymer and Hyaluronic Acid. Macromolecules, 45, (15), 6374 - 6378. https://doi.org/10.1021/ma400996y. Retrieved from https://nsuworks.nova.edu/cnso_chemphys_facarticles/315