Chemistry and Physics Faculty Articles

Title

Discovery and Development of Azasteroids as Anticancer Agents

Document Type

Article

Publication Date

12-2019

Publication Title

Steroids

Keywords

AzasteroidsAnticancer, Steroids, N-glycosides, Nitrogen mustards, 4-Azasteroids

ISSN

0039-128X

Volume

152

First Page

108505

Abstract

Cancer is the second leading cause of death worldwide following cardiovascular diseases. Cancer can be treated by a variety of techniques including surgery, radiation therapy, immunotherapy, and chemotherapy. Choice of the method can be made based on type, physiologic location and the stage of disease progression. Among chemical methods, steroids find broad applications. Azasteroids have N- substitutions in steroidal rings. This structural modification renders azasteroids advantageous in increased effectiveness and reduced side effects. Numerous accounts of cancer efficacy of this family of compounds are available in literature. The progress made in the discovery, synthetic efforts and development of azasteroids as anticancer agents is broadly outlined in this review.

Comments

©2019 Elsevier Inc. All rights reserved.

DOI

10.1016/j.steroids.2019.108505

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Peer Reviewed

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