Discovery and Development of Azasteroids as Anticancer Agents

Authors

Nagaraju Birudukota, Nova Southeastern University
Mukesh Madan Mudgal, Florida International University
Venkatesh M. Shanbhag, Nova Southeastern UniversityFollow

Document Type

Article

Publication Title

Steroids

ISSN

0039-128X

Publication Date

12-2019

Keywords

AzasteroidsAnticancer, Steroids, N-glycosides, Nitrogen mustards, 4-Azasteroids

Abstract

Cancer is the second leading cause of death worldwide following cardiovascular diseases. Cancer can be treated by a variety of techniques including surgery, radiation therapy, immunotherapy, and chemotherapy. Choice of the method can be made based on type, physiologic location and the stage of disease progression. Among chemical methods, steroids find broad applications. Azasteroids have N- substitutions in steroidal rings. This structural modification renders azasteroids advantageous in increased effectiveness and reduced side effects. Numerous accounts of cancer efficacy of this family of compounds are available in literature. The progress made in the discovery, synthetic efforts and development of azasteroids as anticancer agents is broadly outlined in this review.

DOI

10.1016/j.steroids.2019.108505

Volume

152

First Page

108505

Comments

©2019 Elsevier Inc. All rights reserved.

NSUWorks Citation

Birudukota, N., Mudgal, M. M., & Shanbhag, V. M. (2019). Discovery and Development of Azasteroids as Anticancer Agents. Steroids, 152, 108505 - . https://doi.org/10.1016/j.steroids.2019.108505. Retrieved from https://nsuworks.nova.edu/cnso_chemphys_facarticles/266