Chemistry and Physics Faculty Articles
Title
Discovery and Development of Azasteroids as Anticancer Agents
Document Type
Article
Publication Date
12-2019
Publication Title
Steroids
Keywords
AzasteroidsAnticancer, Steroids, N-glycosides, Nitrogen mustards, 4-Azasteroids
ISSN
0039-128X
Volume
152
First Page
108505
Abstract
Cancer is the second leading cause of death worldwide following cardiovascular diseases. Cancer can be treated by a variety of techniques including surgery, radiation therapy, immunotherapy, and chemotherapy. Choice of the method can be made based on type, physiologic location and the stage of disease progression. Among chemical methods, steroids find broad applications. Azasteroids have N- substitutions in steroidal rings. This structural modification renders azasteroids advantageous in increased effectiveness and reduced side effects. Numerous accounts of cancer efficacy of this family of compounds are available in literature. The progress made in the discovery, synthetic efforts and development of azasteroids as anticancer agents is broadly outlined in this review.
NSUWorks Citation
Birudukota, N., Mudgal, M. M., & Shanbhag, V. M. (2019). Discovery and Development of Azasteroids as Anticancer Agents. Steroids, 152, 108505 - . https://doi.org/10.1016/j.steroids.2019.108505. Retrieved from https://nsuworks.nova.edu/cnso_chemphys_facarticles/266
DOI
10.1016/j.steroids.2019.108505
Comments
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