Internal validation of STRmix™ – A multi laboratory response to PCAST

Authors

• Jo-Anne Bright, Institute of Environmental Science and Research Limited
• Rebecca Richards, Institute of Environmental Science and Research Limited
• Maarten Kruijver, Institute of Environmental Science and Research Limited
• Hannah Kelly, Institute of Environmental Science and Research Limited
• Catherine McGovern, Institute of Environmental Science and Research Limited
• Alan Magee, Forensic Science Ireland
• Andrew McWhorter, Texas Department of Public Safety, Houston Laboratory
• Anne Cieko, Midwest Regional Forensic Laboratory, Andover, MN
• Brian Peck, Centre of Forensic Sciences, Toronto
• Chase Baumgartner, Texas Department of Public Safety, Austin Laboratory
• Christina Buettner, Wyoming State Crime Laboratory
• Scott McWilliams, Wyoming State Crime Laboratory
• Claire McKenna, Austin Police Department
• Colin Gallacher, Scottish Police Authority (SPA)
• Ben Mallinder, Scottish Police Authority (SPA)
• Darren Wright, Idaho State Police Forensic Services
• Deven Johnson, Sacramento District Attorney’s Office Laboratory of Forensic Services
• Dorothy Catella, Oakland County Sheriff’s Office
• Eugene Lien, New York City Office of Chief Medical Examiner (OCME)
• Craig O'Connor, New York City Office of Chief Medical Examiner (OCME)
• George Duncan, Broward County Sheriff's Office Crime LaboratoryFollow
• Jason Bundy, Florida Department of Law Enforcement
• Jillian Echard, Connecticut DESPP Division of Scientific Services
• John Lowe, Key Forensic Services Ltd., Warrington Laboratory
• Joshua Stewart, Texas Department of Public Safety, Corpus Christi Laboratory
• Kathleen Corrado, Onondaga County Center for Forensic Sciences
• Sheila Gentile, Onondaga County Center for Forensic Sciences
• Marla Kaplan, Oregon State Police Laboratory (OSP)
• Michelle Hassler, San Diego County Sheriff’s Regional Crime laboratory
• Naomi McDonald, Texas Department of Public Safety, Lubbock Laboratory
• Paul Hulme, Cellmark Forensic Services
• Rachel H. Oefelein, DNA Labs International
• Shawn Montpetit, San Diego Police Department Crime Laboratory
• Melissa Strong, San Diego Police Department Crime Laboratory
• Sarah Noel, Laboratoire de sciences judiciaires et de médecine légale (LSJML) Montréal, Canada
• Simon Malsom, Key Forensic Services Ltd., Norwich Laboratory
• Steven Myers, California Department of Justice Bureau of Forensic Services
• Susan Welti, Department of Forensic Sciences Laboratory, Washington DC (DFS)
• Tamyra Moretti, Federal Bureau of Investigation (FBI)
• Teresa McMahon, Forensic Science Northern Ireland
• Thomas Grill, Erie County Central Services Laboratory
• Tim Kalafut, US Army Criminal Investigation Laboratory (USACIL)
• Mary Margaret Greer-Ritzheimer, DuPage County Sheriff’s Crime Laboratory
• Vickie Beamer, Scottsdale Police Department Crime Laboratory
• Duncan A. Taylor, Forensic Science South Australia; Flinders University
• John S. Buckleton, Institute of Environmental Science and Research Limited; University of Washington

ORCID

0000-0002-4931-5316

Document Type

Article

Publication Title

Forensic Science International: Genetics

ISSN

1872-4973

Publication Date

5-2018

Keywords

PCAST, STRmix, Forensic DNA, Probabilistic genotyping, Continuous models, Validation

Abstract

We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.

DOI

10.1016/j.fsigen.2018.01.003

Volume

34

First Page

11

Last Page

24

NSUWorks Citation

Bright, Jo-Anne; Rebecca Richards; Maarten Kruijver; Hannah Kelly; Catherine McGovern; Alan Magee; Andrew McWhorter; Anne Cieko; Brian Peck; Chase Baumgartner; Christina Buettner; Scott McWilliams; Claire McKenna; Colin Gallacher; Ben Mallinder; Darren Wright; Deven Johnson; Dorothy Catella; Eugene Lien; Craig O'Connor; George Duncan; Jason Bundy; Jillian Echard; John Lowe; Joshua Stewart; Kathleen Corrado; Sheila Gentile; Marla Kaplan; Michelle Hassler; Naomi McDonald; Paul Hulme; Rachel H. Oefelein; Shawn Montpetit; Melissa Strong; Sarah Noel; Simon Malsom; Steven Myers; Susan Welti; Tamyra Moretti; Teresa McMahon; Thomas Grill; Tim Kalafut; Mary Margaret Greer-Ritzheimer; Vickie Beamer; Duncan A. Taylor; and John S. Buckleton. 2018. "Internal validation of STRmix™ – A multi laboratory response to PCAST." Forensic Science International: Genetics 34, (): 11-24. doi:10.1016/j.fsigen.2018.01.003.