Biology Faculty Articles

Title

Distribution of the HLA-DQA1 and Polymarker Alleles in the Basque Population of Spain

Document Type

Article

Publication Date

2-14-2000

Publication Title

Forensic Science International

Keywords

HLA-DQA1, Polymarker, PCR, Basque population

ISSN

0379-0738

Volume

108

Issue/No.

2

First Page

145

Last Page

151

Abstract

HLA-DQA1 and polymarker (LDLR, GYPA, HBGG, D7S8, and GC) genotypic and allelic frequencies are determined for a population sample of 102 unrelated Basque individuals using PCR-based methodology. All six loci met Hardy–Weinberg expectations in at least two of the three analyses performed (HLA-DQA1 failed to meet Hardy–Weinberg requirements in the heterozygote deficiency test). Three linkage analysis programs (GDA, GENEPOP and LINKDOS) detected possible linkage disequilibrium between LDLR and HBGG and results from one (GDA) indicated a possible non-random association between HBGG and HLA-DQA1 as well. Allelic data for the six loci are compared to that previously established for other populations (18 for polymarker alone, 16 for polymarker plus HLA-DQA1) to determine homogeneity between the Basque sample and these groups. According to the results of G-tests based on these loci, the Tadjik, a nomadic Caucasian group from western Asia, and the Basque residents are the only sample populations surveyed that are homogenous with the Basque sample. Phylogenetic analysis places the Basque sample correctly within the Caucasian cluster.

Comments

©2000 Elsevier Science Ireland Ltd. All rights reserved.

ORCID ID

0000-0002-4931-5316

DOI

10.1016/S0379-0738(99)00202-9

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