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Biology Faculty Articles
Title
Distribution of the HLA-DQA1 and Polymarker Alleles in the Basque Population of Spain
Document Type
Article
Publication Date
2-14-2000
Publication Title
Forensic Science International
Keywords
HLA-DQA1, Polymarker, PCR, Basque population
ISSN
0379-0738
Volume
108
Issue/No.
2
First Page
145
Last Page
151
Abstract
HLA-DQA1 and polymarker (LDLR, GYPA, HBGG, D7S8, and GC) genotypic and allelic frequencies are determined for a population sample of 102 unrelated Basque individuals using PCR-based methodology. All six loci met Hardy–Weinberg expectations in at least two of the three analyses performed (HLA-DQA1 failed to meet Hardy–Weinberg requirements in the heterozygote deficiency test). Three linkage analysis programs (GDA, GENEPOP and LINKDOS) detected possible linkage disequilibrium between LDLR and HBGG and results from one (GDA) indicated a possible non-random association between HBGG and HLA-DQA1 as well. Allelic data for the six loci are compared to that previously established for other populations (18 for polymarker alone, 16 for polymarker plus HLA-DQA1) to determine homogeneity between the Basque sample and these groups. According to the results of G-tests based on these loci, the Tadjik, a nomadic Caucasian group from western Asia, and the Basque residents are the only sample populations surveyed that are homogenous with the Basque sample. Phylogenetic analysis places the Basque sample correctly within the Caucasian cluster.
NSUWorks Citation
Brown, Robert J.; Diane Rowold; Mohammed Tahir; Charles Barna; George Duncan; and Rene J. Herrera. 2000. "Distribution of the HLA-DQA1 and Polymarker Alleles in the Basque Population of Spain." Forensic Science International 108, (2): 145-151. doi:10.1016/S0379-0738(99)00202-9.
ORCID ID
0000-0002-4931-5316
DOI
10.1016/S0379-0738(99)00202-9
Comments
©2000 Elsevier Science Ireland Ltd. All rights reserved.