Biology Faculty Articles

Title

Human Phylogenetic Relationships According to the D1S80 Locus

Document Type

Article

Publication Date

1-1996

Publication Title

Genetica

Keywords

Amplified fragment length polymorphism, Forensic PCR analysis, Subpopulation structure

ISSN

0016-6707

Volume

98

Issue/No.

3

First Page

277

Last Page

287

Abstract

By analyzing the allelic frequencies at the D1S80 locus in 43 human populations, we show that the locus is polymorphic globally and that it can be used to discriminate between major racial groups and subpopulations through phylogenetic analysis. Although the use of informative multiple loci generally provides more accurate phylogenetic relationships, in instances where time and/or target DNA availability is limited, D1S80 could provide useful data to discriminate between human groups. Also, knowledge of which loci independently provide accurate phylogenetic relationships, such as the D1S80, can be used to design more accurate multi-locus combinations. In addition, allele frequencies at the locus are reported, for the first time, for Bahamian individuals of African origin and for Chimila, Bari, and Navajo (Cañoncito Valley) native Americans. Allelic data was obtained using standard polymerase chain reaction (PCR) techniques. In the four new populations, 65 genotypes and 20 segregating alleles were observed. All populations conformed to Hardy-Weinberg expectations except the Chimila.

Comments

©1996 Kluwer Academic Publishers

ORCID ID

0000-0002-4931-5316

DOI

10.1007/BF00057592

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Peer Reviewed

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