Biology Faculty Articles
Document Type
Article
Publication Date
9-2016
Publication Title
Genome Biology and Evolution
Keywords
Mammalian dentition, Genes, Adaptive evolution, Positive selection, Tooth-associated genes, Teeth
ISSN
1759-6653
Volume
8
Issue/No.
9
First Page
2748
Last Page
2759
Abstract
A diverse group of genes are involved in the tooth development of mammals. Several studies, focused mainly on mice and rats, have provided a detailed depiction of the processes coordinating tooth formation and shape. Here we surveyed 236 tooth-associated genes in 39 mammalian genomes and tested for signatures of selection to assess patterns of molecular adaptation in genes regulating mammalian dentition. Of the 236 genes, 31 (∼13.1%) showed strong signatures of positive selection that may be responsible for the phenotypic diversity observed in mammalian dentition. Mammalian-specific tooth-associated genes had accelerated mutation rates compared with older genes found across all vertebrates. More recently evolved genes had fewer interactions (either genetic or physical), were associated with fewer Gene Ontology terms and had faster evolutionary rates compared with older genes. The introns of these positively selected genes also exhibited accelerated evolutionary rates, which may reflect additional adaptive pressure in the intronic regions that are associated with regulatory processes that influence tooth-gene networks. The positively selected genes were mainly involved in processes like mineralization and structural organization of tooth specific tissues such as enamel and dentin. Of the 236 analyzed genes, 12 mammalian-specific genes (younger genes) provided insights on diversification of mammalian teeth as they have higher evolutionary rates and exhibit different expression profiles compared with older genes. Our results suggest that the evolution and development of mammalian dentition occurred in part through positive selection acting on genes that previously had other functions.
Additional Comments
Fundacao para a Ciencia e a Tecnologia grant #s: SFRH/BD/65245/2009, SFRH/BD/47938/2008; Russian Ministry of Science mega-grant #: 11.G34.31.0068
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
NSUWorks Citation
Machado, Joao P.; Siby Philip; Emanuel Maldonado; Stephen J. O'Brien; and Warren E. Johnson. 2016. "Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns." Genome Biology and Evolution 8, (9): 2748-2759. doi:10.1093/gbe/evw200.
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
DOI
10.1093/gbe/evw200
Comments
©The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com