Biology Faculty Articles
Document Type
Article
Publication Date
12-1999
Publication Title
Genome Research
ISSN
1088-9051
Volume
9
Issue/No.
12
First Page
1223
Last Page
1230
Abstract
A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes, DFFRY–DBY–UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.
Additional Comments
GenBank accession #s: AF197956-AF197962, AF197964-AF197972
NSUWorks Citation
Murphy, William J.; Shan Sun; Zhang-Qun Chen; Jill Pecon-Slattery; and Stephen J. O'Brien. 1999. "Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping." Genome Research 9, (12): 1223-1230. https://nsuworks.nova.edu/cnso_bio_facarticles/798
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©1999 by Cold Spring Harbor Laboratory Press