Biology Faculty Articles
ORCID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Document Type
Article
Publication Title
PLoS ONE
ISSN
1932-6203
Publication Date
8-18-2006
Abstract
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
Volume
2
Issue
8 e79
First Page
741
Last Page
745
Additional Comments
National Cancer Institute contract #: NO1-CO-12400
NSUWorks Citation
Qi, Ying; Maureen P. Martin; Xiaojiang Gao; Lisa Jacobson; James J. Goedert; Susan Buchbinder; Gregory D. Kirk; Stephen J. O'Brien; John Trowsdale; and Mary Carrington. 2006. "KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections." PLoS ONE 2, (8 e79): 741-745. https://nsuworks.nova.edu/cnso_bio_facarticles/784
Included in
Genetics and Genomics Commons, Immunology and Infectious Disease Commons, Medicine and Health Sciences Commons
Comments
This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.