Biology Faculty Articles
Document Type
Article
Publication Date
9-2009
Publication Title
Emerging Infectious Diseases
ISSN
1080-6040
Volume
15
Issue/No.
9
First Page
1445
Last Page
1452
Abstract
Feline coronavirus (FCoV) is endemic in feral cat populations and cat colonies, frequently preceding outbreaks of fatal feline infectious peritonitis (FIP). FCoV exhibits 2 biotypes: the pathogenic disease and a benign infection with feline enteric coronavirus (FECV). Uncertainty remains regarding whether genetically distinctive avirulent and virulent forms coexist or whether an avirulent form mutates in vivo, causing FIP. To resolve these alternative hypotheses, we isolated viral sequences from FCoV-infected clinically healthy and sick cats (8 FIP cases and 48 FECV-asymptomatic animals); 735 sequences from 4 gene segments were generated and subjected to phylogenetic analyses. Viral sequences from healthy cats were distinct from sick cats on the basis of genetic distances observed in the membrane and nonstructural protein 7b genes. These data demonstrate distinctive circulating virulent and avirulent strains in natural populations. In addition, 5 membrane protein amino acid residues with functional potential differentiated healthy cats from cats with FIP. These findings may have potential as diagnostic markers for virulent FIP-associated FCoV.
Additional Comments
National Cancer Institute contract #: N01-CO-12400
NSUWorks Citation
Brown, Meredith; Jennifer L. Troyer; Jill Pecon-Slattery; M. Roelke-Parker; and Stephen J. O'Brien. 2009. "Genetics and Pathogenesis of Feline Infectious Peritonitis Virus." Emerging Infectious Diseases 15, (9): 1445-1452. https://nsuworks.nova.edu/cnso_bio_facarticles/768
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Included in
Genetics and Genomics Commons, Immunology and Infectious Disease Commons, Zoology Commons
Comments
Published by the Centers for Disease Control and Prevention, a US Government agency.