Biology Faculty Articles
Document Type
Article
Publication Date
12-2009
Publication Title
PLoS ONE
ISSN
1932-6203
Volume
5
Issue/No.
12 e1000791
First Page
1
Last Page
12
Abstract
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Additional Comments
CHAVI grant #: AI067854; National Cancer Institute contract #: HHSN261200800001E
NSUWorks Citation
Fellay, Jacques; Dongliang Ge; Kevin V. Shianna; Sara Colombo; Bruno Ledergerber; Elizabeth T. Cirulli; Thomas J. Urban; Kunlin Zhang; Curtis Gumbs; Jason P. Smith; Antonella Castagna; Alessandro Cozzi-Lepri; Andrea de Luca; Philippa Easterbrook; Huldrych F. Gunthard; Simon Mallal; Cristina Mussini; Judith Dalmau; Javier Martinez-Picado; Jose M. Miro; Niels Obel; Steven M. Wolinsky; Jeremy J. Martinson; Roger Detels; Joseph Margolick; Lisa Jacobson; Patrick Descombes; Stylianos E. Antonarakis; Jacques S. Beckmann; Stephen J. O'Brien; Norman L. Letvin; Andrew J. McMichael; Barton F. Haynes; Mary Carrington; Sheng Feng; Amalio Telenti; David B. Goldstein; and NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). 2009. "Common Genetic Variation and the Control of HIV-1 in Humans." PLoS ONE 5, (12 e1000791): 1-12. https://nsuworks.nova.edu/cnso_bio_facarticles/766
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Included in
Genetics and Genomics Commons, Immunology and Infectious Disease Commons, Medicine and Health Sciences Commons
Comments
This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.