Emerging Viruses in the Felidae: Shifting Paradigms

Authors

• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Jennifer L. Troyer, National Cancer Institute at Frederick
• Meredith Brown, Banfield Pet Hospital
• Warren E. Johnson, National Cancer Institute at Frederick
• Agostinho Antunes, Universidade do Porto - Portugal
• Melody E. Roelke, National Cancer Institute at Frederick
• Jill Pecon-Slattery, National Cancer Institute at Frederick

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Viruses

ISSN

1999-4915

Publication Date

2-2012

Keywords

FIV, FCoV, FeLV, Felidae

Abstract

The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids.

Volume

4

Issue

2

First Page

236

Last Page

257

Comments

©2012 MDPI AG (Basel, Switzerland)

NSUWorks Citation

O'Brien, Stephen J.; Jennifer L. Troyer; Meredith Brown; Warren E. Johnson; Agostinho Antunes; Melody E. Roelke; and Jill Pecon-Slattery. 2012. "Emerging Viruses in the Felidae: Shifting Paradigms." Viruses 4, (2): 236-257. https://nsuworks.nova.edu/cnso_bio_facarticles/755