Biology Faculty Articles
Document Type
Article
Publication Date
2014
Publication Title
BioMed Research International
ISSN
2314-6133
Volume
2014
Issue/No.
434072
First Page
1
Last Page
8
Abstract
Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic role of significant SNPs by calculating the area under the curve (AUC). Results. The reported associations between ITGA9 variants and NPC were not replicated. Multiple loci of GABBR1, HLA-F, HLA-A, and HCG9 were statistically significant in both cohorts (Pcombined range from 5.96 × 10−17 to 0.02). We show for the first time that these factors influence NPC development independent of environmental risk factors. This study also indicated that the SNP alone cannot serve as a predictive/diagnostic marker for NPC. Integrating the most significant SNP with IgA antibodies status to EBV, which is presently used as screening/diagnostic marker for NPC in Chinese populations, did not improve the AUC estimate for diagnosis of NPC.
Additional Comments
National Cancer Institute contract #: HHSN26120080001E; National Natural Science Foundation of China grant #: 30672377; Zhejiang Provincial Top Key Discipline of Laboratory Medicine, Key Science and Technology Innovation Team of Zhejiang Province grant #: 2010R50048
NSUWorks Citation
Guo, Xiuchan; Cheryl Winkler; Ji Li; Li Guan; Minzhong Tang; Jian Liao; Hong Deng; Guy de The; Yi Zeng; and Stephen J. O'Brien. 2014. "Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China." BioMed Research International 2014, (434072): 1-8. https://nsuworks.nova.edu/cnso_bio_facarticles/750
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
© 2014 Xiuchan Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.