Biology Faculty Articles

Authors

Yun Sung Cho, Genome Research Foundation - Republic of Korea
Li Hu, BGI-Shenzhen - China
Haolong Hou, BGI-Shenzhen - China
Hang Lee, Seoul National University - Republic of Korea
Jiaohui Xu, BGI-Shenzhen - China
Soowhan Kwon, Samsung Everland Zoo - Yongin, Republic of Korea
Sukhun Oh, Samsung Everland Zoo - Yongin, Republic of Korea
Hak-Min Kim, Genome Research Foundation - Republic of Korea
Sungwoong Jho, Genome Research Foundation - Republic of Korea
Sangsoo Kim, Soongsil University - Seoul, Republic of Korea
Young-Ah Shin, Genome Research Foundation - Republic of Korea
Byung Chul Kim, Genome Research Foundation - Republic of Korea; Theragen BiO Institute - Republic of Korea
Hyunmin Kim, Theragen BiO Institute - Republic of Korea
Chang-uk Kim, Genome Research Foundation - Republic of Korea
Shu-Jin Luo, Peking University - China
Warren E. Johnson, Smithsonian Conservation Biology Institute
Klaus-Peter Koepfli, St. Petersburg State University - Russia
A. Schmidt-Kunzel, Cheetah Conservation Fund - Namibia
Jason A. Turner, Global White Lion Protection Trust - South Africa
L. Marker, Cheetah Conservation Fund - Namibia
Cindy K. Harper, University of Pretoria - South Africa
Susan M. Miller, University of Pretoria - South Africa; Tshwane University of Technology - Pretoria, South Africa
Wilhelm Jacobs, Ukutula Lodge & Lion Centre - South Africa
Laura D. Bertola, Leiden University - The Netherlands
Tae Hyung Kim, Theragen BiO Institute - Republic of Korea
Sunghoon Lee, Genome Research Foundation - Republic of Korea; Theragen BiO Institute - Republic of Korea
Qian Zhou, BGI-Shenzhen - China
Hyun-Ju Jung, Theragen BiO Institute - Republic of Korea
Xiao Xu, Peking University - Beijing
Priyvrat Gadhvi, Genome Research Foundation - Republic of Korea
Pengwei Xu, BGI-Shenzhen - China
Yingqi Xiong, BGI-Shenzhen - China
Yadan Luo, BGI-Shenzhen - China
Shengkai Pan, BGI-Shenzhen - China
Caiyun Gou, BGI-Shenzhen - China
Xiuhui Chu, BGI-Shenzhen - China
Jilin Zhang, BGI-Shenzhen - China
Sanyang Liu, BGI-Shenzhen - China
Jing He, BGI-Shenzhen - China
Ying Chen, BGI-Shenzhen - China
Linfeng Yang, BGI-Shenzhen - China
Yulan Yang, BGI-Shenzhen - China
Jiaju He, BGI-Shenzhen - China
Sha Liu, BGI-Shenzhen - China
Junyi Wang, BGI-Shenzhen - China
Chul Hong Kim, Theragen BiO Institute - Republic of Korea
Hwanjong Kwak, Theragen BiO Institute - Republic of Korea
Jong-Soo Kim, Genome Research Foundation - Republic of Korea
Seungwoo Hwang, Korea Research Institute of Bioscience and Biotechnology - Republic of Korea
Junsu Ko, Theragen BiO Institute - Republic of Korea
Chang-Bae Kim, Sangmyung University - Seoul, Republic of Korea
Sangtae Kim, Sungshin Women's University - Seoul, Republic of Korea
Damdin Bayarlkhagva, National University of Mongolia
Woon Kee Paek, National Science Museum - Republic of Korea
Seong-Jin Kim, Theragen BiO Institute - Republic of Korea; CHA University - Seoul, Republic of Korea
Stephen J. O'Brien, St. Petersburg State University - Russia; Nova Southeastern UniversityFollow
Jun Wang, BGI-Shenzhen - China; University of Copenhagen - Denmark; King Abdulaziz University - Saudi Arabia
Jong Bhak, Genome Research Foundation - Republic of Korea; Theragen BiO Institute - Republic of Korea; Advanced Institutes of Convergence Technology Nano Science and Technology - Republic of Korea; Seoul National University - Republic of Korea

Document Type

Article

Publication Date

9-17-2013

Publication Title

Nature Communications

ISSN

2041-1723

Volume

4

Issue/No.

2433

First Page

1

Last Page

7

Abstract

Tigers and their close relatives (Panthera) are some of the world’s most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats’ hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.

Comments

©2013 Macmillan Publishers Limited. All rights reserved.

This work is licensed under a Creative Commons Attribution- NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

Additional Comments

Industrial Strategic Technology Development Program #: 10040231; National Research Foundation of Korea grant #: NRF-2011-0019745; South Korean Ministry of Science grant #s: 2012R1A1A2043851, NRF-2008-2004707; Russian Ministry of Science grant #: 11.G34.31.0068; GenBank accession #: ATCQ00000000

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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