Gene Discovery and Data Sharing in Genome Wide Association Analyses: Lessons Form AIDS Genetic Restriction Genes

Authors

• Stephen J. O'Brien, St. Petersburg State University - RussiaFollow
• Anton Svitin, St. Petersburg State University - Russia
• Sergey Malov, St. Petersburg State University - Russia; St. Petersburg Electrotechnical University - Russia
• Nikolay Cherkasov, St. Petersburg State University - Russia
• Pavel Dobrynin, St. Petersburg State University - Russia
• Paul Geerts, Scientific Data Visualization Consultant
• Jennifer L. Troyer, National Cancer Institute at Frederick
• Sher L. Hendrickson, National Cancer Institute at Frederick
• Efe Sezgin, National Cancer Institute at Frederick
• Holli Hutcheson, National Cancer Institute at Frederick

Document Type

Article

Publication Title

Journal of Acquired Immune Deficiency Syndromes

ISSN

1525-4135

Publication Date

3-7-2014

Abstract

As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative statistical associations that straddle the threshold for genome wide significance. At this conference, we shall announce GWATCH, (Genome Wide Association Tracks Chromosome Highway) a web based data release platform that can freely display and inspect unabridged genome tracked association data without compromising privacy or Informed Consent constrictions, allowing for rapid discovery and replication opportunities. We illustrate the utility with HIV-AIDS resistance genes screened in combined large multicenter cohort studies GWAS (MACS, HGDS, MHGS, ALLIVE, LSOCA HOMER) developed and studied over the last decades.

Volume

65

Issue

Supplement 2

First Page

59

Last Page

59

Comments

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

NSUWorks Citation

O'Brien, Stephen J.; Anton Svitin; Sergey Malov; Nikolay Cherkasov; Pavel Dobrynin; Paul Geerts; Jennifer L. Troyer; Sher L. Hendrickson; Efe Sezgin; and Holli Hutcheson. 2014. "Gene Discovery and Data Sharing in Genome Wide Association Analyses: Lessons Form AIDS Genetic Restriction Genes." Journal of Acquired Immune Deficiency Syndromes 65, (Supplement 2): 59-59. https://nsuworks.nova.edu/cnso_bio_facarticles/722