Hypervariable Genomic Variation to Reconstruct the Natural History of Populations: Lessons from the Big Cats

Authors

• Marilyn Menotti-Raymond, National Cancer Institute at Frederick
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Electrophoresis

ISSN

0173-0835

Publication Date

1995

Keywords

DNA fingerprinting, Cheetah, Coefficient of relatedness curve, Cat microsatellites

Abstract

The extent and nature of variation in hypervariable regions of DNA have been used in the past as a means to infer the natural histories of populations. We review the interpretation of the extent of genetic diversity for minisatellite DNA in the cheetah to estimate the timing of a population bottleneck in the species and the potential application of a second class of hypervariable DNA, microsatellite DNA, as a molecular tool to examine the natural histories of felid populations. A calibration curve relating the degree of allele fragment sharing in individuals to relatedness in a captive pedigree of cheetahs is presented. This measurement has important applications for management of potential matings in captive management situations.

Volume

16

Issue

1

First Page

1771

Last Page

1774

Comments

© 1995 VCH Verlagsgesellschaft mbH

NSUWorks Citation

Menotti-Raymond, Marilyn and Stephen J. O'Brien. 1995. "Hypervariable Genomic Variation to Reconstruct the Natural History of Populations: Lessons from the Big Cats." Electrophoresis 16, (1): 1771-1774. https://nsuworks.nova.edu/cnso_bio_facarticles/713