Title

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

Authors

Michael Dean, National Cancer Institute at Frederick
Mary Carrington, National Cancer Institute at Frederick
Cheryl Winkler, National Cancer Institute at Frederick
Gavin A. Huttley, National Cancer Institute at Frederick
Michael W. Smith, National Cancer Institute at Frederick
Rando Allikmets, National Cancer Institute at Frederick
James J. Goedert, National Cancer Institute at Bethesda
Susan Buchbinder, San Francisco Department of Public Health
Eric Vittinghoff, San Francisco Department of Public Health
Edward Gomperts, Childrens Hospital Los Angeles
Sharyne Donfield, New England Research Institute, Incorporated
David Vlahov, Johns Hopkins School of Hygiene and Public Health
Richard A. Kaslow, University of Alabama - Birmingham
A. J. Saah, Johns Hopkins School of Hygiene and Public Health
Charles Rinaldo, University of Pittsburgh
Roger Detels, University of California, Los Angeles
Hemophilia Growth and Development Study
Multicenter AIDS Cohort Study
Multicenter Hemophilia Cohort Study
San Francisco City Cohort
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

9-27-1996

Publication Title

Science

ISSN

0036-8075

Volume

273

Issue/No.

5283

First Page

1856

Last Page

1862

Abstract

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4⁺ T lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 structural gene was mapped to human chromosome 3p21, and a 32-base pair deletion allele (CKR5Δ32) was identified that is present at a frequency of ~0.10 in the Caucasian population of the United States. An examination of 1955 patients included among six well-characterized acquired immunodeficiency syndrome (AIDS) cohort studies revealed that 17 deletion homozygotes occurred exclusively among 612 exposed HIV-1 antibody-negative individuals (2.8 percent) and not at all in 1343 HlV-1-infected individuals. The frequency of CKR5 deletion heterozygotes was significantly elevated in groups of individuals that had survived HIV-1 infection for more than 10 years, and, in some risk groups, twice as frequent as their occurrence in rapid progressors to AIDS. Survival analysis clearly shows that disease progression is slower in CKR5 deletion heterozygotes than in individuals homozygous for the normal CKR5 gene. The CKR5Δ32 deletion may act as a recessive restriction gene against HIV-1 infection and may exert a dominant phenotype of delaying progression to AIDS among infected individuals.

Comments

© 1996 American Association for the Advancement of Science

NSUWorks Citation

Dean, Michael; Mary Carrington; Cheryl Winkler; Gavin A. Huttley; Michael W. Smith; Rando Allikmets; James J. Goedert; Susan Buchbinder; Eric Vittinghoff; Edward Gomperts; Sharyne Donfield; David Vlahov; Richard A. Kaslow; A. J. Saah; Charles Rinaldo; Roger Detels; Hemophilia Growth and Development Study; Multicenter AIDS Cohort Study; Multicenter Hemophilia Cohort Study; San Francisco City Cohort; and Stephen J. O'Brien. 1996. "Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene." Science 273, (5283): 1856-1862. https://nsuworks.nova.edu/cnso_bio_facarticles/696

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015