Title

A Scan for Linkage Disequilibrium Across the Human Genome

Authors

Gavin A. Huttley, National Cancer Institute at Frederick
Michael W. Smith, National Cancer Institute at Frederick
Mary Carrington, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

8-1-1999

Publication Title

Genetics

ISSN

0016-6731

Volume

152

Issue/No.

4

First Page

1711

Last Page

1722

Abstract

Linkage disequilibrium (LD), the tendency for alleles of linked loci to co-occur nonrandomly on chromosomal haplotypes, is an increasingly useful phenomenon for (1) revealing historic perturbation of populations including founder effects, admixture, or incomplete selective sweeps; (2) estimating elapsed time since such events based on time-dependent decay of LD; and (3) disease and phenotype mapping, particularly for traits not amenable to traditional pedigree analysis. Because few descriptions of LD for most regions of the human genome exist, we searched the human genome for the amount and extent of LD among 5048 autosomal short tandem repeat polymorphism (STRP) loci ascertained as specific haplotypes in the European CEPH mapping families. Evidence is presented indicating that ~4% of STRP loci separated by

Comments

©1999 by the Genetics Society of America

Additional Comments

National Cancer Institute contract #: NO1-CO-56000

NSUWorks Citation

Huttley, Gavin A.; Michael W. Smith; Mary Carrington; and Stephen J. O'Brien. 1999. "A Scan for Linkage Disequilibrium Across the Human Genome." Genetics 152, (4): 1711-1722. https://nsuworks.nova.edu/cnso_bio_facarticles/677

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015