Biology Faculty Articles
Document Type
Article
Publication Date
12-15-2002
Publication Title
Cancer Research
ISSN
0008-5472
Volume
62
Issue/No.
24
First Page
7175
Last Page
7180
Abstract
Infection with immunosuppressive lentiviruses is associated with increased cancer risk,but most studies have implicated indirect mechanisms as the tumor cells generally lack integrated viral sequences.An exception wasfound in a B-cell lymphoma (Q254) where the tumor cells contained a single integrated feline immunodeficiency virus genome. Additional analysis now indicates that feline immunodeficiency virus integration in lymphoma Q254 resulted in promoter insertion and truncation of a conserved gene on feline chromosome B3, whereas the unaffected allele of the gene appeared to be transcriptionally down-regulated. The orthologous human gene (FLJ12973), is expressed ubiquitously and encodes a WD-repeat protein with structural similarity to DDB2, the small subunit of the xeroderma pigmentosum XP-E complex. Moreover, the gene is located within a region of frequent tumor-specific deletions on chromosome 15q15. These observations demonstrate the direct mutagenic potential of the lentiviruses and identify a new candidate tumor suppressor gene.
NSUWorks Citation
Beatty, Julia; Anne Terry; Julie MacDonald; Elizabeth Gault; Stanley Cevario; Stephen J. O'Brien; Ewan Cameron; and James C. Neil. 2002. "Feline Immunodeficiency Virus Integration in B-Cell Lymphoma Identifies a Candidate Tumor Suppressor Gene on Human Chromosome 15q151." Cancer Research 62, (24): 7175-7180. https://nsuworks.nova.edu/cnso_bio_facarticles/670
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©2002 American Association for Cancer Research