Biology Faculty Articles
Title
Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5
Document Type
Article
Publication Date
12-4-1998
Publication Title
Science
ISSN
0036-8075
Volume
282
Issue/No.
5395
First Page
1907
Last Page
1911
Abstract
The CCR5 gene encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for macrophage-tropic (R5) strains of human immunodeficiency virus-type 1 (HIV-1). Genetic association analysis of five cohorts of people with acquired immunodeficiency syndrome (AIDS) revealed that infected individuals homozygous for a multisite haplotype of the CCR5 regulatory region containing the promoter allele, CCR5P1, progress to AIDS more rapidly than those with other CCR5 promoter genotypes, particularly in the early years after infection. Composite genetic epidemiologic analyses of genotypes bearing CCR5P1, CCR5-Δ32, CCR2-641, and SDF1-3′A affirmed distinct regulatory influences for each gene on AIDS progression. An estimated 10 to 17 percent of patients who develop AIDS within 3.5 years of HIV-1 infection do so because they are homozygous for CCR5P1/P1, and 7 to 13 percent of all people carry this susceptible genotype. The cumulative and interactive influence of these AIDS restriction genes illustrates the multigenic nature of host factors limiting AIDS disease progression.
NSUWorks Citation
Martin, Maureen P.; Michael Dean; Michael W. Smith; Cheryl Winkler; Bernard Gerrard; Nelson L. Michael; Benhur Lee; Robert W. Doms; Joseph Margolick; Susan Buchbinder; James J. Goedert; Thomas R. O'Brien; Margaret Hilgartner; David Vlahov; Stephen J. O'Brien; and Mary Carrington. 1998. "Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5." Science 282, (5395): 1907-1911. https://nsuworks.nova.edu/cnso_bio_facarticles/664
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©1998 American Association for the Advancement of Science