Title

A Radiation Hybrid Mapping Panel for the Rhesus Macacque

Authors

William J. Murphy, National Cancer Institute at Frederick
J. E. Page, National Cancer Institute at Frederick
C. Smith Jr., National Cancer Institute at Frederick
Ronald C. Desrosiers, Harvard Medical School
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

11-2001

Publication Title

Journal of Heredity

ISSN

0022-1503

Volume

92

Issue/No.

6

First Page

516

Last Page

519

Abstract

The genomes of nonhuman primates have recently become highly visible candidates for full genome analysis, as they provide powerful models of human disease and a better understanding of the evolution of the human genome. We describe the creation of a 5000 rad radiation hybrid (RH) mapping panel for the rhesus macaque. Duplicate genotypes of 84 microsatellite and coding gene sequence tagged sites from six macaque chromosomes produced an estimated whole genome retention frequency of 0.33. To test the mapping ability of the panel, we constructed RH maps for macaque chromosomes 7 and 9 and compared them to orthologous locus orders in existing human and baboon maps derived from different methodologies. Concordant marker order between all three species maps suggests that the current panel represents a powerful mapping resource for generating high-density comparative maps of the rhesus macaque and other species genomes.

Comments

©2001 The American Genetic Association

Additional Comments

GenBank accession #s: AF455790-AF455802

NSUWorks Citation

Murphy, William J.; J. E. Page; C. Smith Jr.; Ronald C. Desrosiers; and Stephen J. O'Brien. 2001. "A Radiation Hybrid Mapping Panel for the Rhesus Macacque." Journal of Heredity 92, (6): 516-519. https://nsuworks.nova.edu/cnso_bio_facarticles/603

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015