Biology Faculty Articles
Title
HLA and AIDS: A Cautionary Tale
Document Type
Article
Publication Date
9-1-2001
Publication Title
Trends in Molecular Medicine
Keywords
AIDS, Major histocompatibility complex, HIV, HLA, MHC, Immunology, Molecular medicine
ISSN
1471-4914
Volume
7
Issue/No.
9
First Page
379
Last Page
381
Abstract
The human major histocompatibility complex HLA has been implicated repeatedly as a regulator of the outcome of HIV exposure and infection. A new study of long-term survivors who naturally depress HIV-1 replication and avoid the signs of AIDS for years after infection suggests that homozygosity for a group of HLA-B locus alleles termed Bw4 confers resistance, ostensibly by regulating natural killer cell–ligand interactions. However, close inspection of the accumulated evidence raises some questions and urges validation of the potential Bw4 effects in additional studies.
NSUWorks Citation
O'Brien, Stephen J.; Xiaojiang Gao; and Mary Carrington. 2001. "HLA and AIDS: A Cautionary Tale." Trends in Molecular Medicine 7, (9): 379-381. https://nsuworks.nova.edu/cnso_bio_facarticles/592
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©2001 Elsevier Science Ltd. All rights reserved.