Title

Human Genes That Limit AIDS

Authors

Stephen J. O'Brien, National Cancer Institute at FrederickFollow
George W. Nelson, National Cancer Institute at Frederick

Document Type

Article

Publication Date

6-2004

Publication Title

Nature Genetics

ISSN

1061-4036

Volume

36

Issue/No.

6

First Page

565

Last Page

574

Abstract

Discernable genetic variation among people and populations has an important role in infectious disease epidemics, including that of acquired immune deficiency syndrome (AIDS). Genetic association analysis of several large AIDS cohorts implicate 14 AIDS restriction genes, polymorphic variants in loci that regulate HIV-1 cell entry, acquired and innate immunity, and cytokine defenses to HIV-1. The influence and translational impact of these genes on individual and population sensitivity to AIDS is considerable.

Comments

©2004 Nature Publishing Group

NSUWorks Citation

O'Brien, Stephen J. and George W. Nelson. 2004. "Human Genes That Limit AIDS." Nature Genetics 36, (6): 565-574. https://nsuworks.nova.edu/cnso_bio_facarticles/580

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015