Biology Faculty Articles

Title

Stromal Cell–Derived Factor–1 Genotype, Coreceptor Tropism, and HIV Type 1 Disease Progression

Document Type

Article

Publication Date

11-1-2005

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

192

Issue/No.

9

First Page

1597

Last Page

1605

Abstract

This study used a well characterized cohort of human immunodeficiency virus type 1 (HIV‐1)–infected hemophiliacs to define the relationship between the SDF1‐3′A allele, the plasma HIV‐1 coreceptor tropism, and the natural history of HIV‐1 disease. Subjects heterozygous or homozygous for the SDF1‐3′A allele experienced higher rates of decline in CD4+ T cell counts over time than did those without the allele (P=.009). Moreover, they had an increased risk of progression to acquired immunodeficiency syndrome and death, a relationship that persisted even when baseline plasma HIV‐1 RNA levels and CD4+ T cell counts or CCR5Δ32 and CCR2‐64I genotype were controlled for. This relationship was even stronger in a subgroup of subjects for whom tropism data were available. Subjects with the SDF1‐3′A allele were also more likely to have detectable X4‐tropic viruses (P=.012), and, when tropism was included in the survival analyses, the effect of the SDF1‐3′A allele on disease progression was no longer significant. Therefore, the increased frequency of X4‐tropic viruses in subjects carrying the SDF1‐3′A allele may explain the observed adverse effect that this allele has on the natural history of HIV‐1 disease.

Comments

©2005 by the Infectious Diseases Society of America

Additional Comments

National Institutes of Health grant and contract #s: HD41224, AI43638, AI27660, NO1-CO-12400; Universitywide AIDS Research Program grant #: CCTG- CC99 SD003; National Institute of Allergy and Infectious Diseases grant #: R44 AI048990

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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