Patterns of Ethnic Diversity Among the Genes That Influence AIDS

Authors

• Cheryl Winkler, National Cancer Institute at Frederick
• Ping An, National Cancer Institute at Frederick
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Human Molecular Genetics

ISSN

0964-6906

Publication Date

4-1-2004

Abstract

Although HIV-1/AIDS emerged late in the last century, more than 42 million individuals have been infected and 25 million have died worldwide, making AIDS, like malaria, a strong selective force for disease-associated genetic factors. Many of the genes that mediate immune response or that are co-opted by HIV-1 for completion of its lifecycle show differences in allele frequencies, as a result of drift, migration or selection. Here we show that the majority of AIDS candidate genes and AIDS restriction genes show significant differences in allele frequencies, possibly the result of historic selective pressures. These genes are undergoing present day natural selection in populations with high AIDS prevalence.

Volume

13

Issue

Suppl. 1

First Page

R9

Last Page

R19

Comments

©2004 Oxford University Press

Additional Comments

National Cancer Institute contract #: N01-CO-12400

NSUWorks Citation

Winkler, Cheryl; Ping An; and Stephen J. O'Brien. 2004. "Patterns of Ethnic Diversity Among the Genes That Influence AIDS." Human Molecular Genetics 13, (Suppl. 1): R9-R19. https://nsuworks.nova.edu/cnso_bio_facarticles/558