Title

AIDS Restriction HLA Allotypes Target Distinct Intervals of HIV-1 Pathogenesis

Authors

Xiaojiang Gao, National Cancer Institute at Frederick
Arman A. Bashirova, Johns Hopkins University
Astrid K. N. Iversen, University of Oxford - United Kingdom
John Phair, Northwestern University Medical School
James J. Goedert, National Cancer Institute at Bethesda
Susan Buchbinder, San Francisco Department of Public Health
Keith Hoots, University of Texas Health Science Center at Houston
David Vlahov, New York Academy of Medicine
Marcus Altfeld, Massachusetts General Hospital
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Mary Carrington, National Cancer Institute at Frederick

Document Type

Article

Publication Date

12-2005

Publication Title

Nature Medicine

ISSN

1078-8956

Volume

11

Issue/No.

12

First Page

1290

Last Page

1292

Abstract

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

Comments

©2005 Nature Publishing Group

Additional Comments

National Cancer Institute contract #: NO1-CO-12400; National Institute on Drug Abuse grant #: DA04334

NSUWorks Citation

Gao, Xiaojiang; Arman A. Bashirova; Astrid K. N. Iversen; John Phair; James J. Goedert; Susan Buchbinder; Keith Hoots; David Vlahov; Marcus Altfeld; Stephen J. O'Brien; and Mary Carrington. 2005. "AIDS Restriction HLA Allotypes Target Distinct Intervals of HIV-1 Pathogenesis." Nature Medicine 11, (12): 1290-1292. https://nsuworks.nova.edu/cnso_bio_facarticles/551

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015