Mapping by Admixture Linkage Disequilibrium: Advances, Limitations and Guidelines

Authors

• Michael W. Smith, National Cancer Institute at Frederick
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Nature Reviews Genetics

ISSN

1471-0056

Publication Date

8-2005

Abstract

Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.

Volume

6

Issue

8

First Page

623

Last Page

632

Comments

©2005 Nature Publishing Group

NSUWorks Citation

Smith, Michael W. and Stephen J. O'Brien. 2005. "Mapping by Admixture Linkage Disequilibrium: Advances, Limitations and Guidelines." Nature Reviews Genetics 6, (8): 623-632. https://nsuworks.nova.edu/cnso_bio_facarticles/533