Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps

Authors

• William J. Murphy, National Cancer Institute at Frederick; Texas A&M University - College Station
• Denis M. Larkin, University of Illinois - Urbana-Champaign
• Annelie Everts-van der Wind, University of Illinois - Urbana-Champaign
• Guillaume Bourque, Genome Institute of Singapore
• Glenn Tesler, University of California - San Diego
• Loretta Auvil, University of Illinois - Urbana-Champaign
• Jonathan E. Beever, University of Illinois - Urbana-Champaign
• Bhanu P. Chowdhary, Texas A&M University - College Station
• Francis Galibert, Universite de Rennes - France
• Lisa Gatzke, University of Illinois - Urbana-Champaign
• Christophe Hitte, Universite de Rennes - France
• Stacey N. Meyers, University of Illinois - Urbana-Champaign
• Denis Milan, Laboratoire de Genetique Cellulaire - France
• Elaine A. Ostrander, National Human Genome Research Institute
• Greg Pape, University of Illinois - Urbana-Champaign
• Heidi G. Parker, National Human Genome Research Institute
• Terje Raudsepp, Texas A&M University - College Station
• Margarita B. Rogatcheva, University of Illinois - Urbana-Champaign
• Lawrence B. Schook, University of Illinois - Urbana-Champaign
• Loren C. Skow, Texas A&M University - College Station
• Michael Welge, University of Illinois - Urbana-Champaign
• James E. Womack, Texas A&M University - College Station
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Pavel Pevzner, University of California - San Diego
• Harris A. Lewin, University of Illinois - Urbana-Champaign

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Science

ISSN

0036-8075

Publication Date

7-22-2005

Abstract

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.

Volume

309

Issue

5734

First Page

613

Last Page

617

Comments

©2005 American Association for the Advancement of Science

Additional Comments

NIH grant #: R01CA-92167; USDA National Research Initiative grant #: AG2004-3520-14196; USDA Cooperative State Research, Education and Extension Service grant #: AG2004-34480-14417; National Cancer Institute contract #: N01-CO-12400

NSUWorks Citation

Murphy, William J.; Denis M. Larkin; Annelie Everts-van der Wind; Guillaume Bourque; Glenn Tesler; Loretta Auvil; Jonathan E. Beever; Bhanu P. Chowdhary; Francis Galibert; Lisa Gatzke; Christophe Hitte; Stacey N. Meyers; Denis Milan; Elaine A. Ostrander; Greg Pape; Heidi G. Parker; Terje Raudsepp; Margarita B. Rogatcheva; Lawrence B. Schook; Loren C. Skow; Michael Welge; James E. Womack; Stephen J. O'Brien; Pavel Pevzner; and Harris A. Lewin. 2005. "Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps." Science 309, (5734): 613-617. https://nsuworks.nova.edu/cnso_bio_facarticles/531