Title

Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps

Authors

William J. Murphy, National Cancer Institute at Frederick; Texas A&M University - College Station
Denis M. Larkin, University of Illinois - Urbana-Champaign
Annelie Everts-van der Wind, University of Illinois - Urbana-Champaign
Guillaume Bourque, Genome Institute of Singapore
Glenn Tesler, University of California - San Diego
Loretta Auvil, University of Illinois - Urbana-Champaign
Jonathan E. Beever, University of Illinois - Urbana-Champaign
Bhanu P. Chowdhary, Texas A&M University - College Station
Francis Galibert, Universite de Rennes - France
Lisa Gatzke, University of Illinois - Urbana-Champaign
Christophe Hitte, Universite de Rennes - France
Stacey N. Meyers, University of Illinois - Urbana-Champaign
Denis Milan, Laboratoire de Genetique Cellulaire - France
Elaine A. Ostrander, National Human Genome Research Institute
Greg Pape, University of Illinois - Urbana-Champaign
Heidi G. Parker, National Human Genome Research Institute
Terje Raudsepp, Texas A&M University - College Station
Margarita B. Rogatcheva, University of Illinois - Urbana-Champaign
Lawrence B. Schook, University of Illinois - Urbana-Champaign
Loren C. Skow, Texas A&M University - College Station
Michael Welge, University of Illinois - Urbana-Champaign
James E. Womack, Texas A&M University - College Station
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Pavel Pevzner, University of California - San Diego
Harris A. Lewin, University of Illinois - Urbana-Champaign

Document Type

Article

Publication Date

7-22-2005

Publication Title

Science

ISSN

0036-8075

Volume

309

Issue/No.

5734

First Page

613

Last Page

617

Abstract

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.

Comments

©2005 American Association for the Advancement of Science

Additional Comments

NIH grant #: R01CA-92167; USDA National Research Initiative grant #: AG2004-3520-14196; USDA Cooperative State Research, Education and Extension Service grant #: AG2004-34480-14417; National Cancer Institute contract #: N01-CO-12400

NSUWorks Citation

Murphy, William J.; Denis M. Larkin; Annelie Everts-van der Wind; Guillaume Bourque; Glenn Tesler; Loretta Auvil; Jonathan E. Beever; Bhanu P. Chowdhary; Francis Galibert; Lisa Gatzke; Christophe Hitte; Stacey N. Meyers; Denis Milan; Elaine A. Ostrander; Greg Pape; Heidi G. Parker; Terje Raudsepp; Margarita B. Rogatcheva; Lawrence B. Schook; Loren C. Skow; Michael Welge; James E. Womack; Stephen J. O'Brien; Pavel Pevzner; and Harris A. Lewin. 2005. "Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps." Science 309, (5734): 613-617. https://nsuworks.nova.edu/cnso_bio_facarticles/531

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015