Biology Faculty Articles
Title
Searching for Signals of Evolutionary Selection in 168 Genes Related to Immune Function
Document Type
Article
Publication Date
3-2006
Publication Title
Human Genetics
Keywords
Metabolic diseases, Gene function, Molecular medicine, Human genetics
ISSN
0340-6717
Volume
119
Issue/No.
1-2
First Page
92
Last Page
102
Abstract
Pathogens have played a substantial role in human evolution, with past infections shaping genetic variation at loci influencing immune function. We selected 168 genes known to be involved in the immune response, genotyped common single nucleotide polymorphisms across each gene in three population samples (CEPH Europeans from Utah, Han Chinese from Guangxi, and Yoruba Nigerians from Southwest Nigeria) and searched for evidence of selection based on four tests for non-neutral evolution: minor allele frequency (MAF), derived allele frequency (DAF), Fst versus heterozygosity and extended haplotype homozygosity (EHH). Six of the 168 genes show some evidence for non-neutral evolution in this initial screen, with two showing similar signals in independent data from the International HapMap Project. These analyses identify two loci involved in immune function that are candidates for having been subject to evolutionary selection, and highlight a number of analytical challenges in searching for selection in genome-wide polymorphism data.
Additional Comments
National Cancer Institute contracat #: NO1-CO-12400
NSUWorks Citation
Walsh, Emily C.; Pardis Sabeti; Holli Hutcheson; Ben Fry; Stephen F. Schaffner; Paul I. W. de Bakker; Patrick Varilly; Alejandro A. Palma; Jessica Roy; Richard Cooper; Cheryl Winkler; Yi Zeng; Guy de The; Eric S. Lander; Stephen J. O'Brien; and David Altshuler. 2006. "Searching for Signals of Evolutionary Selection in 168 Genes Related to Immune Function." Human Genetics 119, (1-2): 92-102. https://nsuworks.nova.edu/cnso_bio_facarticles/530
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©Springer-Verlag 2005