Title

Evaluation of IL10, IL19 and IL20 Gene Polymorphisms and Chronic Hepatitis B Infection Outcome

Authors

Ann L. Truelove, National Cancer Institute at Frederick
T. K. Oleksyk, National Cancer Institute at Frederick
Sadeep Shrestha, National Cancer Institute at Frederick
Chloe L. Thio, Johns Hopkins University
James J. Goedert, National Cancer Institute at Rockville
Sharyne Donfield, Rho, Inc.
Gregory D. Kirk, Johns Hopkins University
David L. Thomas, Johns Hopkins University
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Michael W. Smith, National Cancer Institute at Frederick

Document Type

Article

Publication Date

6-2008

Publication Title

International Journal of Immunogenetics

ISSN

1744-3121

Volume

35

Issue/No.

3

First Page

255

Last Page

264

Abstract

Hepatitis B virus (HBV) infection remains a serious global health problem despite the availability of a highly effective vaccine. Approximately 5% of HBV-infected adults develop chronic hepatitis B, which may result in liver cirrhosis or hepatocellular carcinoma. Variants of interleukin-10 (IL10) have been previously associated with chronic hepatitis B infection and progression to hepatocellular carcinoma. Single nucleotide polymorphisms (SNP; n = 42) from the IL10, IL19 and IL20 gene regions were examined for an association with HBV infection outcome, either chronic or recovered, in a nested case–control study of African Americans and European Americans. Among African Americans, three nominally statistically significant SNP associations in IL10, two in IL20, and one haplotype association were observed with different HBV infection outcomes (P = 0.005–0.04). A SNP (rs1518108) in IL20 deviated significantly from Hardy–Weinberg equilibrium in African Americans, with a large excess of heterozygotes in chronic HBV-infected cases (P = 0.0006), which suggests a strong genetic effect. Among European Americans, a nominally statistically significant SNP association in IL20 and an IL20haplotype were associated with HBV recovery (P = 0.01–0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis.

Comments

©2008 Blackwell Publishing Ltd

Additional Comments

National Cancer Institute contract #: N01-CO-12400; NIH grant #: R01 DA13324

NSUWorks Citation

Truelove, Ann L.; T. K. Oleksyk; Sadeep Shrestha; Chloe L. Thio; James J. Goedert; Sharyne Donfield; Gregory D. Kirk; David L. Thomas; Stephen J. O'Brien; and Michael W. Smith. 2008. "Evaluation of IL10, IL19 and IL20 Gene Polymorphisms and Chronic Hepatitis B Infection Outcome." International Journal of Immunogenetics 35, (3): 255-264. https://nsuworks.nova.edu/cnso_bio_facarticles/506

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015