Title

Association of Y Chromosome Haplogroup I with HIV Progression, and HAART Outcome

Authors

Efe Sezgin, National Cancer Institute at Frederick
Joanne M. Lind, National Cancer Institute at Frederick; University of Western Sydney - Australia
Sadeep Shrestha, National Cancer Institute at Frederick; University of Alabama - Birmingham
Sher L. Hendrickson, National Cancer Institute at Frederick
James J. Goedert, National Cancer Institute at Rockville
Sharyne Donfield, Rho, Inc.
Gregory D. Kirk, Johns Hopkins University
John Phair, Northwestern University Medical School
Jennifer L. Troyer, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Michael W. Smith, National Cancer Institute at Frederick

Document Type

Article

Publication Date

4-2009

Publication Title

Human Genetics

ISSN

0340-6717

Volume

125

Issue/No.

3

First Page

281

Last Page

294

Abstract

The host genetic basis of differential outcomes in HIV infection, progression, viral load set point and highly active retroviral therapy (HAART) responses was examined for the common Y haplogroups in European Americans and African Americans. Accelerated progression to acquired immune deficiency syndrome (AIDS) and related death in European Americans among Y chromosome haplogroup I (Y-I) subjects was discovered. Additionally, Y-I haplogroup subjects on HAART took a longer time to HIV-1 viral suppression and were more likely to fail HAART. Both the accelerated progression and longer time to viral suppression results observed in haplogroup Y-I were significant after false-discovery-rate corrections. A higher frequency of AIDS-defining illnesses was also observed in haplogroup Y-I. These effects were independent of the previously identified autosomal AIDS restriction genes. When the Y-I haplogroup subjects were further subdivided into six I subhaplogroups, no one subhaplogroup accounted for the effects on HIV progression, viral load or HAART response. Adjustment of the analyses for population stratification found significant and concordant haplogroup Y-I results. The Y chromosome haplogroup analyses of HIV infection and progression in African Americans were not significant. Our results suggest that one or more loci on the Y chromosome found on haplogroup Y-I have an effect on AIDS progression and treatment responses in European Americans.

Comments

©US Government 2009

Additional Comments

National Cancer Institute contract #: N01-CO-12400; National Institutes of Health grant #: 1 R01 HD41224

NSUWorks Citation

Sezgin, Efe; Joanne M. Lind; Sadeep Shrestha; Sher L. Hendrickson; James J. Goedert; Sharyne Donfield; Gregory D. Kirk; John Phair; Jennifer L. Troyer; Stephen J. O'Brien; and Michael W. Smith. 2009. "Association of Y Chromosome Haplogroup I with HIV Progression, and HAART Outcome." Human Genetics 125, (3): 281-294. https://nsuworks.nova.edu/cnso_bio_facarticles/470

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015