Association of Y Chromosome Haplogroup I with HIV Progression, and HAART Outcome

Authors

• Efe Sezgin, National Cancer Institute at Frederick
• Joanne M. Lind, National Cancer Institute at Frederick; University of Western Sydney - Australia
• Sadeep Shrestha, National Cancer Institute at Frederick; University of Alabama - Birmingham
• Sher L. Hendrickson, National Cancer Institute at Frederick
• James J. Goedert, National Cancer Institute at Rockville
• Sharyne Donfield, Rho, Inc.
• Gregory D. Kirk, Johns Hopkins University
• John Phair, Northwestern University Medical School
• Jennifer L. Troyer, National Cancer Institute at Frederick
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Michael W. Smith, National Cancer Institute at Frederick

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Human Genetics

ISSN

0340-6717

Publication Date

4-2009

Abstract

The host genetic basis of differential outcomes in HIV infection, progression, viral load set point and highly active retroviral therapy (HAART) responses was examined for the common Y haplogroups in European Americans and African Americans. Accelerated progression to acquired immune deficiency syndrome (AIDS) and related death in European Americans among Y chromosome haplogroup I (Y-I) subjects was discovered. Additionally, Y-I haplogroup subjects on HAART took a longer time to HIV-1 viral suppression and were more likely to fail HAART. Both the accelerated progression and longer time to viral suppression results observed in haplogroup Y-I were significant after false-discovery-rate corrections. A higher frequency of AIDS-defining illnesses was also observed in haplogroup Y-I. These effects were independent of the previously identified autosomal AIDS restriction genes. When the Y-I haplogroup subjects were further subdivided into six I subhaplogroups, no one subhaplogroup accounted for the effects on HIV progression, viral load or HAART response. Adjustment of the analyses for population stratification found significant and concordant haplogroup Y-I results. The Y chromosome haplogroup analyses of HIV infection and progression in African Americans were not significant. Our results suggest that one or more loci on the Y chromosome found on haplogroup Y-I have an effect on AIDS progression and treatment responses in European Americans.

Volume

125

Issue

3

First Page

281

Last Page

294

Comments

©US Government 2009

Additional Comments

National Cancer Institute contract #: N01-CO-12400; National Institutes of Health grant #: 1 R01 HD41224

NSUWorks Citation

Sezgin, Efe; Joanne M. Lind; Sadeep Shrestha; Sher L. Hendrickson; James J. Goedert; Sharyne Donfield; Gregory D. Kirk; John Phair; Jennifer L. Troyer; Stephen J. O'Brien; and Michael W. Smith. 2009. "Association of Y Chromosome Haplogroup I with HIV Progression, and HAART Outcome." Human Genetics 125, (3): 281-294. https://nsuworks.nova.edu/cnso_bio_facarticles/470