Feline Immunodeficiency Virus (FIV) in Wild Pallas' Cats

Authors

• Meredith Brown, National Cancer Institute at Frederick
• Bariushaa Munkhtsog, Mongolian Academy of Sciences - Ulaan Baatar, Mongolia
• Jennifer L. Troyer, National Cancer Institute at Frederick
• Steve Ross, University of Bristol - United Kingdom
• Rani Sellers, Yeshiva University Bronx
• Amanda E. Fine, Wildlife Conservation Society - Ulaanbaatar, Mongolia
• William Swanson, Cincinnati Zoo and Botanical Garden
• Melody E. Roelke, National Cancer Institute at Frederick
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Veterinary Immunology and Immunopathology

ISSN

0165-2427

Publication Date

3-15-2010

Keywords

FIV, Pallas’ cat, Evolution, Histopathology, Felidae

Abstract

Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas’ cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIV_Oma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas’ cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIV_Oma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas’ cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas’ cats suggests that FIV_Oma causes immune depletion in its’ native host.

Volume

134

Issue

1-2

First Page

90

Last Page

95

Comments

©2009 Elsevier B.V. All rights reserved.

Additional Comments

National Cancer Institute contract #: N01-CO-12400; GenBank accession #s: GQ370820-GQ370824

NSUWorks Citation

Brown, Meredith; Bariushaa Munkhtsog; Jennifer L. Troyer; Steve Ross; Rani Sellers; Amanda E. Fine; William Swanson; Melody E. Roelke; and Stephen J. O'Brien. 2010. "Feline Immunodeficiency Virus (FIV) in Wild Pallas' Cats." Veterinary Immunology and Immunopathology 134, (1-2): 90-95. https://nsuworks.nova.edu/cnso_bio_facarticles/461