Title

Mitochondrial Haplogroups Are Associated With Risk of Neuroretinal Disorder in HIV-Positive Patients

Authors

Sher L. Hendrickson, National Cancer Institute at Frederick
Douglas A. Jabs, Mount Sinai School of Medicine
Mark Van Natta, Johns Hopkins University
Richard Alan Lewis, Baylor College of Medicine
Douglas C. Wallace, University of California - Irvine
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

4-1-2010

Publication Title

Journal of Acquired Immune Deficiency Syndromes

Keywords

AIDS, Mitochondrial DNA, Neuroretinal disorder

ISSN

1525-4135

Volume

53

Issue/No.

4

First Page

451

Last Page

455

Abstract

Although highly active antiretroviral therapy has improved survivorship dramatically and decreased the incidence of cytomegalovirus retinitis among patients with AIDS, other ophthalmic complications continue to occur. One complication observed in ∼12% of HIV-infected patients is a presumed neuroretinal disorder (NRD), manifested as decreased contrast sensitivity and associated with vague subjective complaints of hazy vision. Pathologically, patients with AIDS even without ocular opportunistic infections have loss of optic nerve axons, suggestive of mitochondrial dysfunction. We explored whether variation in mitochondrial DNA was associated with time to NRD in HIV-infected patients in the Longitudinal Study of Ocular Complications of AIDS cohort. Within the Western European, or “N”, mitochondrial DNA macrohaplogroup, haplogroup J, was associated with 80% decrease in the risk of progression to NRD during the study (hazard ratio = 0.20, P = 0.039) and suggested an independent association with protection against NRD in a cross-section of all patients taken at enrollment (1.5% vs. 8.9% in patients with vs. without haplogroup J, respectively, P = 0.05). These data suggest that mitochondrial genotype may influence propensity to develop HIV-associated NRD in patients with AIDS.

Comments

© 2010 Lippincott Williams & Wilkins, Inc.

Additional Comments

National Cancer Institute contract #: N01-CO-12400; National Eye Institute agreement #s: U10 EY 08052, U10 EY 08057, U10 EY 08067

NSUWorks Citation

Hendrickson, Sher L.; Douglas A. Jabs; Mark Van Natta; Richard Alan Lewis; Douglas C. Wallace; and Stephen J. O'Brien. 2010. "Mitochondrial Haplogroups Are Associated With Risk of Neuroretinal Disorder in HIV-Positive Patients." Journal of Acquired Immune Deficiency Syndromes 53, (4): 451-455. https://nsuworks.nova.edu/cnso_bio_facarticles/454

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015