Title

Effect of Host Genetics on Incidence of HIV Neuroretinal Disorder in Patients with AIDS

Authors

Efe Sezgin, National Cancer Institute at Frederick
Sher L. Hendrickson, National Cancer Institute at Frederick
Douglas A. Jabs, Mount Sinai School of Medicine; Johns Hopkins University
Mark Van Natta, Johns Hopkins University
Richard A. Lewis, Baylor College of Medicine
Jennifer L. Troyer, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
SOCA Research Group

Document Type

Article

Publication Date

8-1-2010

Publication Title

Journal of Acquired Immune Deficiency Syndromes

Keywords

AIDS, HIV-1, Host genetics, HIV-neuroretinal disorder

ISSN

1525-4135

Volume

54

Issue/No.

4

First Page

343

Last Page

351

Abstract

Approximately 10%-15% of patients with AIDS but without ocular opportunistic infections will have a presumed neuroretinal disorder (HIV-NRD), manifested by reduced contrast sensitivity and abnormal visual fields. The loss of contrast sensitivity often is sufficient to impair reading speed. To evaluate the effect of host genetics on HIV-NRD, we explored validated AIDS restriction gene variants CCR5Δ32, CCR2-64I, CCR5 P1, SDF-3'A, IL-10-5'A, RANTES -403A, RANTES -28G, RANTES-In1.1C, CX3CR1-249I, CX3CR1-280M, IFNG-179T, MDR1-3435T, and MCP-1364G, each of which has been implicated previously to influence HIV-1 infection, AIDS progression, therapy response, and antiviral drug metabolism, and an IL-10 receptor gene, IL-10R1, in the Longitudinal Study of the Ocular Complications of AIDS cohort. In European Americans (cases = 55, controls = 290), IL-10-5'A variant and its promoter haplotype (hazard ratio = 2.09, confidence interval. 1.19 to 3.67, P = 0.01), in African Americans (cases = 54, controls = 180), RANTES-In1.1C and the associated haplotype (hazard ratio = 2.72, confidence interval.: 1.48 to 5.00, P = 0.001), showed increased HIV-NRD susceptibility. Although sample sizes are small and P values do not pass a strict Bonferroni correction, our results suggest that, in European Americans, an IL-10-related pathway, and, in African Americans, chemokine receptor ligand polymorphisms in RANTES are risk factors for HIV-NRD development. Clearly, further studies are warrented.

Comments

©2010 by Lippincott Williams & Wilkins

Additional Comments

National Cancer Institute contract #s: N01-CO-12400, HHSN26120080001E; National Eye Institute agreement #s: U10-EY-08052, U10-EY-08057, U10-EY-08067

NSUWorks Citation

Sezgin, Efe; Sher L. Hendrickson; Douglas A. Jabs; Mark Van Natta; Richard A. Lewis; Jennifer L. Troyer; Stephen J. O'Brien; and SOCA Research Group. 2010. "Effect of Host Genetics on Incidence of HIV Neuroretinal Disorder in Patients with AIDS." Journal of Acquired Immune Deficiency Syndromes 54, (4): 343-351. https://nsuworks.nova.edu/cnso_bio_facarticles/452

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015