Biology Faculty Articles

Title

Minke Whale Genome and Aquatic Adaptation in Cetaceans

Authors

Hyung-Soon Yim, Korea Institute of Ocean Science and Technology - Republic of Korea
Yun Sung Cho, Genome Research Foundation - Republic of Korea
Xuanmin Guang, BGI-Shenzhen - China
Sung Gyun Kang, Korea Institute of Ocean Science and Technology - Republic of Korea; University of Science and Technology - Daejeon, Republic of Korea
Jae-Yeon Jeong, Korea Institute of Ocean Science and Technology - Republic of Korea; niversity of Science and Technology - Daejeon, Republic of Korea
Sun-Shin Cha, Korea Institute of Ocean Science and Technology - Republic of Korea; niversity of Science and Technology - Daejeon, Republic of Korea; Korea Maritime University - Busan, Republic of Korea
Hyun-Myung Oh, Korea Institute of Ocean Science and Technology - Republic of Korea
Jae-Hak Lee, Korea Institute of Ocean Science and Technology - Republic of Korea
Eun Chan Yang, Korea Institute of Ocean Science and Technology - Republic of Korea
Kae Kyoung Kwon, Korea Institute of Ocean Science and Technology - Republic of Korea; niversity of Science and Technology - Daejeon, Republic of Korea
Yun Jae Kim, Korea Institute of Ocean Science and Technology - Republic of Korea
Tae Wan Kim, Korea Institute of Ocean Science and Technology - Republic of Korea
Wonduck Kim, Korea Institute of Ocean Science and Technology - Republic of Korea
Jeong Ho Jeon, Korea Institute of Ocean Science and Technology - Republic of Korea
Sang-Jin Kim, Korea Institute of Ocean Science and Technology - Republic of Korea; niversity of Science and Technology - Daejeon, Republic of Korea
Dong Han Choi, Korea Institute of Ocean Science and Technology - Republic of Korea
Sungwoong Jho, Genome Research Foundation - Republic of Korea
Hak-Min Kim, Genome Research Foundation - Republic of Korea
Junsu Ko, Theragen BiO Institute - Republic of Korea
Hyunmin Kim, Theragen BiO Institute - Republic of Korea
Young-Ah Shin, Genome Research Foundation - Republic of Korea
Hyun-Ju Jung, Theragen BiO Institute - Republic of Korea
Yuan Zheng, BGI-Shenzhen - China
Zhuo Wang, BGI-Shenzhen - China
Yan Chen, BGI-Shenzhen - China
Ming Chen, BGI-Shenzhen - China
Awei Jiang, BGI-Shenzhen - China
Erli Li, BGI-Shenzhen - China
Shu Zhang, BGI-Shenzhen - China
Haolong Hou, Shaanxi Yulin Energy Group Co. Ltd. - China
Tae Hyung Kim, Theragen BiO Institute - Republic of Korea
Lili Yu, BGI-Shenzhen - China
Sha Liu, BGI-Shenzhen - China
Kung Ahn, Theragen BiO Institute - Republic of Korea
Jesse Cooper, Theragen BiO Institute - Republic of Korea
Sing-Gi Park, Theragen BiO Institute - Republic of Korea
Chang Pyo Hong, Theragen BiO Institute - Republic of Korea
Wook Jin, Gachon University - Incheon, Republic of Korea
Heui-Soo Kim, Pusan National University - Busan, Republic of Korea
Chankyu Park, Konkuk University - Seoul, Republic of Korea
Kyooyeol Lee, Konkuk University - Seoul, Republic of Korea
Sung Chun, Brigham and Women's Hospital and Harvard Medical School
Phillip A. Morin, National Marine Fisheries Service
Stephen J. O'Brien, St. Petersburg State University - RussiaFollow
Hang Lee, Seoul National University - Republic of Korea
Jumpei Kimura, Seoul National University - Republic of Korea
Dae Yeon Moon, Marine Biodiversity Institute of Korea - Sejong, Republic of Korea
Andrea Manica, University of Cambridge - United Kingdom
Jeremy Edwards, University of New Mexico - Albuquerque
Byung Chul Kim, Genome Research Foundation - Republic of Korea
Sangsoo Kim, Soongsil University - Seoul, Republic of Korea
Jun Wang, BGI-Shenzhen - China; University of Copenhagen - Denmark; King Abdulaziz University - Saudi Arabia
Jong Bhak, Genome Research Foundation - Republic of Korea; Theragen BiO Institute - Republic of Korea; Advanced Institutes of Convergence Technology Nano Science and Technology - Republic of Korea; Seoul National University - Republic of Korea
Hyun Sook Lee, Korea Institute of Ocean Science and Technology - Republic of Korea; niversity of Science and Technology - Daejeon, Republic of Korea
Jung-Hyun Lee, Korea Institute of Ocean Science and Technology - Republic of Korea; niversity of Science and Technology - Daejeon, Republic of Korea

Document Type

Article

Publication Date

1-2014

Publication Title

Nature Genetics

ISSN

1061-4036

Volume

46

Issue/No.

1

First Page

88

Last Page

92

Abstract

The shift from terrestrial to aquatic life by whales was a substantial evolutionary event. Here we report the whole-genome sequencing and de novo assembly of the minke whale genome, as well as the whole-genome sequences of three minke whales, a fin whale, a bottlenose dolphin and a finless porpoise. Our comparative genomic analysis identified an expansion in the whale lineage of gene families associated with stress-responsive proteins and anaerobic metabolism, whereas gene families related to body hair and sensory receptors were contracted. Our analysis also identified whale-specific mutations in genes encoding antioxidants and enzymes controlling blood pressure and salt concentration. Overall the whale-genome sequences exhibited distinct features that are associated with the physiological and morphological changes needed for life in an aquatic environment, marked by resistance to physiological stresses caused by a lack of oxygen, increased amounts of reactive oxygen species and high salt levels.

Comments

©2014 Nature America, Inc. All rights reserved.

Additional Comments

Korea Institute of Ocean Science and Technology program #: PE98993, Industrial Strategic Technology Development Program #: 10040231; Russian Ministry of Science grant #: 11.G34.31.0068; GenBank accession #: ATDI01000000

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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Peer Reviewed

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